Proteomic analysis of the Echinococcus granulosus metacestode during infection of its intermediate host

Proteomics
Karina M MonteiroHenrique Bunselmeyer Ferreira

Abstract

Cystic hydatid disease (CHD) is caused by infection with the Echinococcus granulosus metacestode and affects both humans and livestock. In this work, we performed a proteomic analysis of the E. granulosus metacestode during infection of its intermediate bovine host. Parasite proteins were identified in different metacestode components (94 from protoscolex, 25 from germinal layer and 20 from hydatid cyst fluid), along with host proteins (58) that permeate into the hydatid cyst, providing new insights into host-parasite interplay. E. granulosus and platyhelminth EST data allowed successful identification of proteins potentially involved in downregulation of host defenses, highlighting possible evasion mechanisms adopted by the parasite to establish infection. Several intracellular proteins were found in hydatid cyst fluid, revealing a set of newly identified proteins that were previously thought to be inaccessible for inducing or modulating the host immune response. Host proteins identified in association with the hydatid cyst suggest that the parasite may bind/adsorb host molecules with nutritional and/or immune evasion purposes, masking surface antigens or inhibiting important effector molecules of host immunity, such as comple...Continue Reading

References

Mar 1, 1996·Analytical Chemistry·A ShevchenkoM Mann
Jan 1, 1997·Parasite Immunology·A L Colebrook, M W Lightowlers
May 16, 1998·Genome Research·D GordonP Green
May 29, 2000·Trends in Genetics : TIG·P RiceA Bleasby
Apr 12, 2001·International Journal of Experimental Pathology·A O'Regan, J S Berman
Dec 26, 2001·Bioinformatics·H H Chou, M H Holmes
Oct 3, 2002·The Biochemical Journal·Carmen LorenzoGualberto González-Sapienza
Sep 13, 2003·BMC Bioinformatics·Roman L TatusovDarren A Natale
Apr 15, 2004·Immunology Letters·Dominic O CoMatyas Sandor
Apr 30, 2004·Protein Engineering, Design & Selection : PEDS·Jannick Dyrløv BendtsenSøren Brunak
Jun 30, 2004·Journal of Molecular Biology·Jannick Dyrløv BendtsenSøren Brunak
Feb 3, 2005·Nature Reviews. Immunology·Shoshana Levy, Tsipi Shoham
Feb 9, 2005·Biochimica Et Biophysica Acta·Gustavo ChemaleArnaldo Zaha
May 4, 2005·Parasitology International·Geoffrey N Gobert, Donald P McManus
Aug 23, 2005·Molecular & Cellular Proteomics : MCP·Giselle M KnudsenJames H McKerrow
Jan 3, 2006·Parasitology International·Peter M Schantz
Feb 24, 2006·Emerging Infectious Diseases·Christine M BudkePaul R Torgerson
Mar 21, 2006·International Journal for Parasitology·Jaap J Van HellemondAloysius G M Tielens
Mar 11, 2008·Experimental Parasitology·Alessandra SiracusanoAntonella Teggi
Apr 29, 2008·Molecular and Biochemical Parasitology·James P HewitsonRick M Maizels
Jul 17, 2008·PLoS Neglected Tropical Diseases·Elizabeth HansellJames H McKerrow
Jul 22, 2008·Molecular and Biochemical Parasitology·Ricardo Pérez-SánchezAna Oleaga
Sep 3, 2008·Developmental and Comparative Immunology·Hélène SchroederAlain Vanderplasschen
Oct 22, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Pedro Moro, Peter M Schantz
Dec 17, 2008·Parasitology·M J G JohnstonD M McKay
Mar 21, 2009·Molecular & Cellular Proteomics : MCP·Feng LiuZe-Guang Han
May 2, 2009·Molecular and Biochemical Parasitology·James P HewitsonRick M Maizels

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Citations

Oct 19, 2010·Parasitology Research·Alice LaschukHenrique B Ferreira
Feb 1, 2013·Clinical and Vaccine Immunology : CVI·Zohreh Kazemi MoghadamRahmah Noordin
Mar 14, 2012·PLoS Neglected Tropical Diseases·Karina M MonteiroHenrique B Ferreira
Nov 24, 2011·Clinical & Developmental Immunology·Alessandra SiracusanoElena Ortona
Apr 29, 2014·Experimental Parasitology·José Navarrete-PereaJuan P Laclette
Feb 14, 2016·Veterinary Parasitology·Christian HidalgoRodolfo Paredes
Mar 8, 2013·Experimental Parasitology·Akiko GotoYukiharu Sawada
Oct 2, 2015·Parasite Immunology·A DíazA M Ferreira
Dec 20, 2015·Parasite Immunology·F TamarozziE Brunetti
May 25, 2012·Proteomics·Bjorn VictorMagnus Palmblad
Dec 6, 2014·Environmental Science and Pollution Research International·Florence Arsène-PloetzeChristine Carapito
Jan 21, 2012·Molecular and Biochemical Parasitology·Veridiana G VirginioHenrique B Ferreira
Aug 16, 2014·International Journal for Parasitology·R C A Thompson, D J Jenkins
Sep 18, 2016·Molecular and Biochemical Parasitology·Rita Leal SperottoSibele Borsuk
Apr 27, 2017·Journal of Proteomics·Karina M MonteiroHenrique B Ferreira
Mar 16, 2017·Veterinary Parasitology·Mar Siles-LucasRaúl Manzano-Román
Dec 18, 2016·Molecular and Biochemical Parasitology·Rémi LonguespéeJörg Kriegsmann
Nov 8, 2017·World Journal of Hepatology·Nikica M GruborYehuda Shoenfeld
Nov 22, 2017·Parasites & Vectors·Anna SulimaDaniel Młocicki
Sep 24, 2015·PLoS Neglected Tropical Diseases·João Antonio DebarbaArnaldo Zaha
Nov 27, 2018·Parasite : Journal De La Société Française De Parasitologie·Hui WangHao Wen
Jan 26, 2020·International Journal of Molecular Sciences·Zhi HeGuangyou Yang

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