Proteomic analysis of the skin of Chinese giant salamander (Andrias davidianus)

Journal of Proteomics
Xiaofang GengCunshuan Xu

Abstract

The Chinese giant salamander (Andrias davidianus), renowned as a living fossil, is the largest and longest-lived amphibian species in the world. Its skin has developed mucous gland which could secrete a large amount of mucus under the scraping and electric stimulation, and the molting is the degraded skin stratum corneum. Although several proteomic studies have focused on functional proteomes of mammalian and frog skin, the skin proteome of Chinese giant salamander has not yet been carefully studied. To establish the functional skin proteome of Chinese giant salamander, two-dimensional gel electrophoresis (2DE) and mass spectrometry (MS) were applied to detect the composition and relative abundance of the proteins in the skin, mucus and molting. Our findings indicated that 249 proteins were identified in the skin, 155 proteins in the mucus, and 97 proteins in the molting. Furthermore, Gene Ontology (GO) analysis showed that these proteins participated in various physiological activities, including extracellular matrix organization, defense, immune response, wound healing, respiration, etc. In conclusion, the proteomic results provide new insight in the aspects of the proteomes in the skin, mucus and the molting of Chinese giant...Continue Reading

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Citations

Jun 28, 2016·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Jingyan SunCunshuan Xu
Nov 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoyun LiXiaoying Wang
Sep 22, 2017·Cellular & Molecular Biology Letters·Chunyan ZhangCunshuan Xu
Jul 2, 2020·Conservation Physiology·Abbey E WilsonDavid M Janz

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