Proteomic analysis of the TerC interactome: Novel links to tellurite resistance and pathogenicity

Journal of Proteomics
L TurkovicovaJ Aradska

Abstract

The tellurite resistance gene operon (ter) is widely spread among bacterial species, particularly pathogenic species. The ter operon has been implicated in tellurite resistance, phage inhibition, colicine resistance, and pathogenicity. The TerC protein represents one of the key proteins in tellurite resistance and shows no significant homology to any protein of known function. So far, there is no experimental evidence for TerC interaction partners. In this study, proteomic-based methods, including blue native electrophoresis and co-immunoprecipitation combined with LC-MS/MS, have been used to identify TerC interaction partners and thus providing indirect evidence for tentative functions of TerC in Escherichia coli. An interactome has been constructed and robust physical interaction of integral membrane protein TerC with TerB, DctA, PspA, HslU, and RplK has been shown. The TerC-TerB complex appears to act as a central unit that may link different functional modules with biochemical activities of C4-dicarboxylate transport, inner membrane stress response (phage shock protein regulatory complex), ATPase/chaperone activity, and proteosynthesis. In previous reports, it was hypothesized that a transmembrane unit formed by TerC protei...Continue Reading

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Citations

Feb 27, 2020·International Journal of Systematic and Evolutionary Microbiology·Miia PasanenMinna Pirhonen
Mar 5, 2020·The Journal of Antimicrobial Chemotherapy·Zhenpeng LiFang Bai
Feb 27, 2018·PeerJ·Claudia Melissa Muñoz-VillagránClaudio Christian Vásquez
Mar 3, 2020·Frontiers in Cellular and Infection Microbiology·Hannah BekebredeYasuko Rikihisa
Nov 5, 2020·Pathogens·Saksakon ParatsaphanPiengchan Sonthayanon
Jun 15, 2021·Frontiers in Microbiology·Thi Thu Huong NguyenAtsushi Iguchi

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