Proteomic Architecture of Human Coronary and Aortic Atherosclerosis

David M HerringtonJennifer E Van Eyk


The inability to detect premature atherosclerosis significantly hinders implementation of personalized therapy to prevent coronary heart disease. A comprehensive understanding of arterial protein networks and how they change in early atherosclerosis could identify new biomarkers for disease detection and improved therapeutic targets. Here we describe the human arterial proteome and proteomic features strongly associated with early atherosclerosis based on mass spectrometry analysis of coronary artery and aortic specimens from 100 autopsied young adults (200 arterial specimens). Convex analysis of mixtures, differential dependent network modeling, and bioinformatic analyses defined the composition, network rewiring, and likely regulatory features of the protein networks associated with early atherosclerosis and how they vary across 2 anatomic distributions. The data document significant differences in mitochondrial protein abundance between coronary and aortic samples (coronary>aortic), and between atherosclerotic and normal tissues (atherosclerotic<normal), and major alterations in tumor necrosis factor, insulin receptor, peroxisome proliferator-activated receptor-α, and peroxisome proliferator-activated receptor-γ protein netw...Continue Reading


Oct 18, 2000·Nature·H JeongA L Barabási
Nov 25, 2003·Analytical Chemistry·Alexey I NesvizhskiiRuedi Aebersold
Dec 19, 2003·Nucleic Acids Research·Rolf ApweilerLai-Su L Yeh
Jan 23, 2004·PLoS Biology·Sven BergmannNaama Barkai
Oct 22, 2004·Molecular & Cellular Proteomics : MCP·Estelle M FachGregory J Opiteck
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Bin Zhang, Steve Horvath
Dec 17, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B PorcelliL Terzuoli
Dec 25, 2009·Circulation. Cardiovascular Genetics·Manuel MayrChantal M Boulanger
Jan 1, 2009·Annals of Statistics·Hui Zou, Hao Helen Zhang
Jun 17, 2010·Molecular & Cellular Proteomics : MCP·Athanasios DidangelosManuel Mayr
Aug 14, 2010·Circulation Research·John R MercerMartin Bennett
Oct 5, 2010·Biochemical and Biophysical Research Communications·Fredrik J OlsonGöran Bergström
Jan 21, 2011·Molecular & Cellular Proteomics : MCP·Fernando de la CuestaFernando Vivanco
Feb 8, 2011·Bioinformatics·Bai ZhangYue Wang
May 20, 2011·Molecular & Cellular Proteomics : MCP·Athanasios DidangelosManuel Mayr
Oct 11, 2011·Nature Methods·Alexandre KuhnRuth Luthi-Carter
Jan 19, 2012·Molecular Systems Biology·Trey Ideker, Nevan J Krogan
Jun 6, 2012·Methods in Molecular Biology·Christine Vogel, Edward M Marcotte
Aug 2, 2012·BMC Genomics·Nicholas J HudsonAntonio Reverter
Sep 12, 2012·Nature Biotechnology·Pau CreixellRune Linding
Feb 22, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Jerry GuintivanoZachary A Kaminsky
Sep 14, 2013·IUBMB Life·David I LeavesleyZee Upton
Sep 21, 2013·Nature Reviews. Genetics·Koyel MitraTrey Ideker
Oct 23, 2013·Journal of the American Heart Association·Qian ChenIftikhar J Kullo
Nov 28, 2014·Nucleic Acids Research·Gene Ontology Consortium
Apr 25, 2015·Circulation Research·Iftikhar J Kullo, Nicholas J Leeper
May 5, 2016·Nature·Jianxi GaoAlbert-László Barabási
Aug 9, 2016·Nature Reviews. Genetics·Jessica Xin HuSøren Brunak
Jun 8, 2017·Nature Communications·Ismail SerginBabak Razani
Oct 13, 2017·Nature·GTEx ConsortiumStephen B Montgomery
Nov 15, 2017·Nature Communications·Sophia DollMatthias Mann


Jan 9, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ali NehmeKazem Zibara
Apr 12, 2019·Current Opinion in Cardiology·Scot J Matkovich
Jan 3, 2020·Circulation Research·Mark W Majesky
Jun 5, 2020·Circulation Research·Christoph D RauYibin Wang
Jul 7, 2020·International Journal of Molecular Medicine·Yaqing ZhouEnzhi Jia
Jul 6, 2019·Frontiers in Physiology·Danbo LuJunbo Ge
Jul 6, 2020·Lipids in Health and Disease·Wen-Song YangPeng Xie
Nov 11, 2019·Diagnostics·Ekaterina M StakhnevaYuliya I Ragino
Aug 11, 2020·Cancer Metastasis Reviews·Robert ClarkeYue Wang
Mar 21, 2020·Npj Regenerative Medicine·D Kent ArrellAndre Terzic
Dec 4, 2020·Proteomics. Clinical Applications·Salah A MohamedOliver Klein
May 2, 2020·Journal of the American College of Cardiology·Javier Barallobre-BarreiroJason C Kovacic

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