Proteomic Architecture of Human Coronary and Aortic Atherosclerosis

Circulation
David M HerringtonJennifer E Van Eyk

Abstract

The inability to detect premature atherosclerosis significantly hinders implementation of personalized therapy to prevent coronary heart disease. A comprehensive understanding of arterial protein networks and how they change in early atherosclerosis could identify new biomarkers for disease detection and improved therapeutic targets. Here we describe the human arterial proteome and proteomic features strongly associated with early atherosclerosis based on mass spectrometry analysis of coronary artery and aortic specimens from 100 autopsied young adults (200 arterial specimens). Convex analysis of mixtures, differential dependent network modeling, and bioinformatic analyses defined the composition, network rewiring, and likely regulatory features of the protein networks associated with early atherosclerosis and how they vary across 2 anatomic distributions. The data document significant differences in mitochondrial protein abundance between coronary and aortic samples (coronary>aortic), and between atherosclerotic and normal tissues (atherosclerotic<normal), and major alterations in tumor necrosis factor, insulin receptor, peroxisome proliferator-activated receptor-α, and peroxisome proliferator-activated receptor-γ protein netw...Continue Reading

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Related Concepts

Aorta
Arteries
Atherosclerosis
Autopsy
Biological Markers
Chronic Disease
Coronary Arteriosclerosis
Coronary Heart Disease
Plasma
Insulin Receptor

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