Proteomic-based prediction of clinical behavior in adult acute lymphoblastic leukemia

Cancer
M AlbitarH M Kantarjian

Abstract

Response in adult acute lymphoblastic leukemia (ALL) can be achieved in a majority of patients. However, unlike pediatric ALL, recurrence is common in adult ALL, and the ability to predict at an early stage which patients are most likely to experience recurrence may help in devising new therapeutic approaches to prevent recurrence. Peripheral blood plasma from 57 patients with confirmed ALL was obtained before induction therapy for proteomic analysis. Follow-up continued for a median period of 71 weeks. For each plasma sample, 4 fractions eluted from a strong anion column were applied to 3 different ProteinChip array surfaces, and 12 surface-enhanced laser desorption/ionization (SELDI) spectra were generated. Peaks that correlated with recurrence were identified and decision trees were constructed and evaluated, using only 2 peaks per predictive tree. The best decision trees provided strong positive prediction of recurrence, with correct predictions 84% to 92% of the time, whereas negative prediction of patients who did not experience recurrence was less robust, with 62% to 74% accuracy. Prediction of recurrence was independent of cytogenetics, bone marrow blast count, lactate dehydrogenase, beta-2-microglobulin, or surface mar...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L Anderson, N G Anderson
Sep 1, 1992·Electrophoresis·G J HughesD F Hochstrasser
Feb 28, 2002·Plant Molecular Biology·David FinkelsteinShauna Somerville
Aug 27, 2002·BMC Bioinformatics·Ravi KothapalliThomas P Loughran
Nov 25, 2003·Leukemia Research·Hana BruchovaRadim Brdicka
Nov 25, 2003·British Journal of Haematology·Francis J GilesMaher Albitar
Jan 7, 2004·Biotechnology and Bioengineering·G R GrantC J Stoeckert
Jan 14, 2004·Molecular & Cellular Proteomics : MCP·N Leigh AndersonAnna Lobley
Apr 9, 2004·The New England Journal of Medicine·Ching-Hon PuiJames R Downing
Jun 9, 2004·Critical Reviews in Oncology/hematology·Renato BassanRoel Willemze
Jul 9, 2004·Pathology, Research and Practice·Jan C Wiemer, Alexander Prokudin
Jan 14, 2005·International Journal of Hematology·Adolfo A Ferrando, A Thomas Look

❮ Previous
Next ❯

Citations

Jan 15, 2013·Analytical and Bioanalytical Chemistry·Ibon IloroFelix Elortza
Apr 28, 2012·International Journal of Hematology·Aili HeFuling Zhou
Sep 17, 2009·Journal of Proteomics·Alberto Zamò, Daniela Cecconi
Nov 24, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Suzanne SmitAge K Smilde
Sep 25, 2007·Blood Reviews·Richard D Unwin, Anthony D Whetton
Dec 30, 2014·Journal of Cellular and Molecular Medicine·Elena López VillarWilliam C Cho
Mar 27, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Patrizia ChiusoloMassimo Castagnola
Sep 30, 2010·The Korean Journal of Parasitology·Young Yil BahkTong-Soo Kim
Aug 4, 2006·American Journal of Physiology. Cell Physiology·Thuy D Vo, Bernhard O Palsson
Oct 22, 2019·Future Medicinal Chemistry·Tiantian ZhangChanghu Xue
Aug 8, 2021·Cancers·Alexandra NeagaMihnea Zdrenghea

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Valérie ParadisPierre Bedossa
Proteomics
Lynne ThadikkaranJean-Daniel Tissot
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jiu-Wei CuiXue-Min Zhang
Expert Review of Anticancer Therapy
Akos CzibereManuel Aivado
© 2021 Meta ULC. All rights reserved