Proteomic Biomarkers for Incident Aortic Stenosis Requiring Valvular Replacement

Circulation
Johan LjungbergStefan Söderberg

Abstract

Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untreated AS is linked to high mortality. The etiological background of AS is unknown. Previous human studies were typically based on case-control studies. Biomarkers identified in prospective studies could lead to novel mechanistic insights. Within a large population survey with blood samples obtained at baseline, 334 patients were identified who later underwent surgery for AS (median age [interquartile range], 59.9 [10.4] years at survey and 68.3 [12.7] at surgery; 48% female). For each case, 2 matched referents were allocated. Plasma was analyzed with the multiplex proximity extension assay for screening of 92 cardiovascular candidate proteins. Conditional logistic regression models were used to assess associations between each protein and AS, with correction for multiple testing. A separate set of 106 additional cases with 212 matched referents was used in a validation study. Six proteins (growth differentiation factor 15, galectin-4, von Willebrand factor, interleukin 17 receptor A, transferrin receptor protein 1, and proprotein convertase subtilisin/kexin type 9) were associated with case status in the discovery cohort; odds ratios ranged ...Continue Reading

References

Nov 13, 2001·The American Journal of Cardiology·W S AronowI Kronzon
Mar 27, 2010·Global Health Action·Margareta NorbergLars Weinehall
Jan 11, 2012·International Journal of Immunopathology and Pharmacology·C FalconeG Pelissero
Jan 22, 2013·International Journal of Cardiology·Hisashi SawadaTohru Masuyama
Oct 29, 2013·Journal of the American College of Cardiology·Pia R KamstrupBørge G Nordestgaard
Aug 26, 2014·The Canadian Journal of Cardiology·Jutta Bergler-KleinGerald Maurer
Dec 3, 2014·International Journal of Cardiology·Gerd BaldenhoferFabian Knebel
Aug 4, 2015·Biometrics·Shaun R Seaman, Ruth H Keogh
Dec 15, 2015·Mediators of Inflammation·Ruirui ZhuYucheng Zhong
Mar 28, 2016·Protein & Cell·Zhan-Qi Cao, Xiu-Li Guo
May 18, 2016·Nature Reviews. Disease Primers·Brian R LindmanPhilippe Pibarot
Nov 7, 2016·Journal of the American Heart Association·J Rafael SádabaNatalia López-Andrés
Feb 6, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Aeron SmallDaniel J Rader
Aug 5, 2017·PloS One·Stergios TzikasTill Keller

❮ Previous
Next ❯

Citations

May 26, 2018·Diabetologia·Christoph NowakJohan Ärnlöv
Aug 23, 2019·Journal of the American Heart Association·Eva Warensjö LemmingKarl Michaëlsson
May 6, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Michael A RaddatzW David Merryman
Dec 12, 2020·Archives of Biochemistry and Biophysics·Yanan GuoXi-Long Zheng
Aug 26, 2021·Cardiovascular Research·Francesca Bartoli-LeonardElena Aikawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.