Proteomic characterization of host response to Yersinia pestis and near neighbors

Biochemical and Biophysical Research Communications
Brett A ChromySandra L McCutchen-Maloney

Abstract

Host-pathogen interactions result in protein expression changes within both the host and the pathogen. Here, results from proteomic characterization of host response following exposure to Yersinia pestis, the causative agent of plague, and to two near neighbors, Yersinia pseudotuberculosis and Yersinia enterocolitica, are reported. Human monocyte-like cells were chosen as a model for macrophage immune response to pathogen exposure. Two-dimensional electrophoresis followed by mass spectrometry was used to identify host proteins with differential expression following exposure to these three closely related Yersinia species. This comparative proteomic characterization of host response clearly shows that host protein expression patterns are distinct for the different pathogen exposures, and contributes to further understanding of Y. pestis virulence and host defense mechanisms. This work also lays the foundation for future studies aimed at defining biomarkers for presymptomatic detection of plague.

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Citations

Nov 18, 2005·Journal of Bacteriology·Brett A ChromySandra L McCutchen-Maloney
Feb 5, 2010·Journal of Biomedicine & Biotechnology·Todd H CorzettBrett A Chromy
May 29, 2007·Microbial Pathogenesis·James V RogersCarol L K Sabourin
Jul 25, 2008·Insect Molecular Biology·H S GatehouseJ T Christeller
Aug 14, 2012·Scandinavian Journal of Immunology·Y BiR Yang
Aug 21, 2007·European Journal of Immunology·Inna LindnerKelvin P Lee
May 17, 2005·Expert Review of Proteomics·Celia G ZhangSandra L McCutchen-Maloney
May 17, 2005·Expert Review of Proteomics·Richard R DrakeStefan Gravenstein
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Aarti GautamMarti Jett

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