Abstract
Hypokalemic nephropathy caused by prolonged K(+) deficiency is associated with metabolic alkalosis, polydipsia, polyuria, growth retardation, hypertension, and progressive tubulointerstitial injury. Its pathophysiology, however, remains unclear. We performed gel-based, differential proteomics analysis of kidneys from BALB/c mice fed with high-normal-K(+) (HNK), low-normal-K(+) (LNK), or K(+)-depleted diet for 8 wk (n = 6 in each group). Plasma K(+) levels were 4.62 +/- 0.35, 4.46 +/- 0.23, and 1.51 +/- 0.21 mmol/L for HNK, LNK, and KD mice, respectively (p < 0.0001; KD vs. others). With comparable amounts of food intake, the KD mice drank significantly more water than the other two groups and had polyuria. Additionally, the KD mice had growth retardation, metabolic alkalosis, markedly enlarged kidneys, renal tubular dilation, intratubular deposition of amorphous and laminated hyaline materials, and tubular atrophy. A total of 33 renal proteins were differentially expressed between the KD mice and others, whereas only eight proteins were differentially expressed between the HNK and LNK groups, as determined by quantitative intensity analysis and ANOVA with Tukey's post hoc multiple comparisons. Using MALDI-MS and/or quadrupole-T...Continue Reading
References
Sep 1, 1977·The Journal of Clinical Investigation·T BerlR J Anderson
Dec 1, 1986·The Journal of Clinical Investigation·G CapassoG Giebisch
May 1, 1987·The Journal of Clinical Investigation·J P TolinsT H Hostetter
Mar 1, 1986·The Journal of Clinical Investigation·D A Maddox, F J Gennari
Jan 1, 1980·Kidney International·D L StetsonG Giebisch
Jan 1, 1996·Annual Review of Physiology·R P Henry
Sep 1, 1996·Kidney International·T NakanishiY Takamitsu
Apr 16, 1998·The Journal of Clinical Investigation·H AmlalM Soleimani
Aug 13, 1998·The New England Journal of Medicine·F J Gennari
Jun 23, 2000·The Journal of Biological Chemistry·T BenzingG Walz
Jun 27, 2000·Nephron·A J BrantenJ F Wetzels
Sep 9, 2000·Archives of Internal Medicine·J N CohnL M Prisant
Oct 18, 2000·Biochemical and Biophysical Research Communications·K AidaT Onaya
Apr 25, 2001·Kidney International·P E RayR J Johnson
Oct 19, 2001·The Journal of Biological Chemistry·D SterlingJ R Casey
Nov 7, 2001·The Journal of Biological Chemistry·B C TrippJ G Ferry
Nov 13, 2001·Kidney International·J N FryerD Z Levine
Jan 5, 2002·Free Radical Biology & Medicine·Fabienne DesmotsAndré Guillouzo
Apr 16, 2002·The EMBO Journal·Anna KaganThomas V McDonald
Jun 11, 2002·Critical Care Clinics·F John Gennari
Jun 20, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Gillian CresseyChristopher P Snowden
Jun 22, 2002·The Journal of Biological Chemistry·Thomas BenzingEmily Kim
Jul 11, 2002·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·T KimuraH Shiiki
Jul 18, 2002·The Journal of Biological Chemistry·Visith ThongboonkerdJon B Klein
Sep 18, 2002·Kidney International·John M ArthurJon B Klein
Nov 16, 2002·The Journal of Physiology·Sindhu RajanJürgen Daut
Aug 2, 1956·The New England Journal of Medicine·A S RELMAN, W B SCHWARTZ
Nov 20, 2003·Proteomics·Mark P MolloyRuth A VanBogelen
Nov 20, 2003·Proteomics·Doris E Terry, Dominic M Desiderio
Dec 3, 2003·Contributions to Nephrology·Visith ThongboonkerdJon B Klein
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Visith ThongboonkerdJon B Klein
Apr 20, 2004·Cellular and Molecular Life Sciences : CMLS·J M Petrash
May 29, 2004·The Biochemical Journal·Carol Mackintosh
Jun 19, 2004·American Journal of Nephrology·Visith Thongboonkerd
Jul 31, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuying C HwangRavichandran Ramasamy
Aug 18, 2004·Biochemical Pharmacology·Ying Xia, Winston W-Y Kao
Sep 8, 2004·Journal of Molecular and Cellular Cardiology·Erik Wilker, Michael B Yaffe
Dec 22, 2004·The Plant Journal : for Cell and Molecular Biology·Paul W J van den WijngaardAlbertus H De Boer
Jan 26, 2005·Proteomics·Visith Thongboonkerd, Prida Malasit
Apr 29, 2005·Cell Research·Paulette Mhawech
Jun 15, 2005·Journal of Proteome Research·Sybille M N HuntMarc R Wilkins
Jul 8, 2005·Expert Review of Proteomics·Visith Thongboonkerd
Citations
Jun 21, 2011·Acta Pharmacologica Sinica·Hong LuLi-ying Zhu
May 23, 2012·Antioxidants & Redox Signaling·David SheehanBrian McDonagh
Jul 15, 2011·American Journal of Physiology. Renal Physiology·Ki-Hwan HanI David Weiner
Jul 26, 2008·PLoS Computational Biology·Wannipha TongsimaPrasit Palittapongarnpim
Jul 24, 2014·PloS One·Hong LuJie Chen
Nov 4, 2010·Seminars in Nephrology·Ana VelicCarsten A Wagner
Mar 16, 2016·Biochimica Et Biophysica Acta·Paleerath PeerapenVisith Thongboonkerd
Aug 1, 2009·Proteomics. Clinical Applications·Hermann Lage
Aug 22, 2007·Proteomics·Sven FratermanMatthias Wilm
May 1, 2008·Proteomics. Clinical Applications·Nicolas BousetteThomas Kislinger
Sep 1, 2008·Proteomics. Clinical Applications·Ratree TavichakorntrakoolVisith Thongboonkerd
Apr 4, 2017·Journal of Proteome Research·Yeap S NgDouglas A Brooks
Aug 19, 2017·Cell Adhesion & Migration·Chompunoot Kapincharanon, Visith Thongboonkerd
Dec 1, 2006·Nutrition Research Reviews·Helen R Griffiths, Melissa M Grant
Nov 17, 2006·American Journal of Physiology. Renal Physiology·Michael G JanechJohn M Arthur
Apr 25, 2014·American Journal of Physiology. Renal Physiology·Lene StødkildeJørgen Frøkiaer
Apr 10, 2009·Journal of Proteome Research·Phattara-Orn Havanapan, Visith Thongboonkerd
Nov 6, 2007·Journal of Proteome Research·Sa-Nga PattanakitsakulVisith Thongboonkerd
Mar 10, 2007·Journal of Proteome Research·Visith ThongboonkerdSunee Korbsrisate