Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups.

Molecular & Cellular Proteomics : MCP
Yu LiuLunzhi Dai

Abstract

Gastrointestinal stromal tumor (GIST) is a common sarcoma of gastrointestinal tract (GIT) with high metastatic and recurrence rates, but the proteomic features are still less understood. Here we performed systematic quantitative proteome profiling of GIST from 13 patients classified into very low/low, intermediate and high risk subgroups. An extended cohort of GIST (n = 131) was used for immunohistochemical validation of proteins of interest. In total, 9177 proteins were quantified, covering 55.9% of the GIT transcriptome from The Human Protein Altas. Out of the 9177 quantified proteins, 4930 proteins were observed in all 13 cases with 517 upregulated and 187 downregulated proteins in tumorous tissues independent of risk stage. Pathway analysis showed that the downregulated proteins were mostly enriched in metabolic pathway, whereas the upregulated proteins mainly belonged to spliceosome pathway. In addition, 131 proteins showed differentially expressed patterns among GIST subgroups with statistical significance. The 13 GIST cases were classified into 3 subgroups perfectly based on the expression of these proteins. The intensive comparison of molecular phenotypes and possible functions of quantified oncoproteins, tumor suppress...Continue Reading

References

Apr 1, 1994·American Journal of Obstetrics and Gynecology·J R WienerR C Bast
May 19, 2000·Experimental and Molecular Pathology·M WarabiK Hirokawa
Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Jul 3, 2002·Human Pathology·Markku MiettinenJerzy Lasota
Nov 9, 2002·The Lancet Oncology·Heikki JoensuuGeorge Demetri
Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Jun 30, 2004·The American Journal of Surgical Pathology·Fabiola MedeirosChristopher D M Fletcher
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher L CorlessMichael C Heinrich
Dec 30, 2006·Seminars in Diagnostic Pathology·Markku Miettinen, Jerzy Lasota
Feb 21, 2007·Nature Structural & Molecular Biology·Rotem KarniAdrian R Krainer
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoshiyuki SueharaSetsuo Hirohashi
Jul 11, 2008·Genes, Chromosomes & Cancer·Narasimhan P AgaramCristina R Antonescu
Jul 17, 2009·The American Journal of Surgical Pathology·Markku MiettinenJerzy Lasota
Jul 22, 2009·Archives of Surgery·Charles E WoodallRobert C G Martin
Sep 29, 2009·Biochimica Et Biophysica Acta·Laurent LessardMichel L Tremblay
Apr 6, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P W T PistersUNKNOWN reGISTry Steering Committee
Jul 9, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P RutkowskiH Joensuu
Oct 25, 2011·International Journal of Cancer. Journal International Du Cancer·Irma KluijtUNKNOWN Dutch Working Group on Hereditary Gastric Cancer
Jan 14, 2012·Expert Opinion on Therapeutic Targets·Parthasarathy SeshacharyuluSurinder K Batra
Jan 17, 2012·Nature Structural & Molecular Biology·Olga AnczukówAdrian R Krainer
Mar 24, 2012·Science·You-Qiang SuJohn J Eppig
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Apr 30, 2013·Lancet·Heikki JoensuuChristopher L Corless
May 17, 2013·Nature·Linfeng WuMichael Snyder
May 9, 2014·Molecular Cancer Research : MCR·Shipra Das, Adrian R Krainer
Jan 24, 2015·Science·Mathias UhlénFredrik Pontén
Nov 26, 2015·Nature Reviews. Genetics·Marina M Scotti, Maurice S Swanson
Oct 8, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jeong Mo BaeGyeong Hoon Kang
Jan 12, 2017·International Journal of Molecular Medicine·Shaomin ShiZhongsen Ma
Sep 28, 2017·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Jian Li Chinese Society Of Clinical Oncology Csco Expert Committee On Gastrointestinal Stromal Tumor

❮ Previous
Next ❯

Citations

Nov 14, 2019·Seminars in Cancer Biology·Jessica BurnsPaul H Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Related Papers

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
Seiichi Hirota
JBR-BTR : Organe De La Société Royale Belge De Radiologie (SRBR) = Orgaan Van De Koninklijke Belgische Vereniging Voor Radiologie (KBVR)
F van der Straaten
Annals of Oncology : Official Journal of the European Society for Medical Oncology
I Judson
© 2022 Meta ULC. All rights reserved