Proteomic overview and perspectives of the radiation-induced bystander effects

Mutation Research. Reviews in Mutation Research
François ChevalierJean-Louis Lefaix

Abstract

Radiation proteomics is a recent, promising and powerful tool to identify protein markers of direct and indirect consequences of ionizing radiation. The main challenges of modern radiobiology is to predict radio-sensitivity of patients and radio-resistance of tumor to be treated, but considerable evidences are now available regarding the significance of a bystander effect at low and high doses. This "radiation-induced bystander effect" (RIBE) is defined as the biological responses of non-irradiated cells that received signals from neighboring irradiated cells. Such intercellular signal is no more considered as a minor side-effect of radiotherapy in surrounding healthy tissue and its occurrence should be considered in adapting radiotherapy protocols, to limit the risk for radiation-induced secondary cancer. There is no consensus on a precise designation of RIBE, which involves a number of distinct signal-mediated effects within or outside the irradiated volume. Indeed, several cellular mechanisms were proposed, including the secretion of soluble factors by irradiated cells in the extracellular matrix, or the direct communication between irradiated and neighboring non-irradiated cells via gap junctions. This phenomenon is observe...Continue Reading

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Citations

Apr 25, 2018·Journal of Experimental & Clinical Cancer Research : CR·Le TangZhaoyang Zeng
Mar 25, 2019·Journal of Cell Communication and Signaling·Charlotte LepleuxFrançois Chevalier
Dec 28, 2019·International Journal of Molecular Sciences·Juliette ThariatFrançois Chevalier
Sep 10, 2019·Technology in Cancer Research & Treatment·Francois ChevalierYannick Saintigny
Aug 18, 2018·Oxidative Medicine and Cellular Longevity·Mihaela TemelieNicoleta Moisoi
Nov 3, 2020·Drug Discovery Today·Sandeep Kumar ShuklaM H Yashavarddhan
Aug 8, 2021·International Journal of Molecular Sciences·Mihaela TudorFrançois Chevalier

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