Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: potential roles in GABAergic interneuron pathology

Schizophrenia Research
Klaus Oliver SchubertDavid R Cotter

Abstract

Neuropathological changes of the hippocampus have been associated with psychotic disorders such as schizophrenia and bipolar disorder. Recent work has particularly implicated hippocampal GABAergic interneurons in the pathophysiology of these diseases. However, the molecular mechanisms underlying structural and cellular hippocampal pathology remain poorly understood. We used data from comprehensive difference-in-gel electrophoresis (2-D DIGE) investigations of postmortem human hippocampus of people with schizophrenia and bipolar disorder, covering the acidic (isoelectric point (pI) between pH4 and 7) and, separately, the basic (pI between pH6 and 11) sub-proteome, for Ingenuity Pathway Analysis (IPA) of implicated protein networks and pathways. Comparing disease and control cases, we identified 58 unique differentially expressed proteins in schizophrenia, and 70 differentially expressed proteins in bipolar disorder, using mass spectrometry. IPA implicated, most prominently, 14-3-3 and aryl hydrocarbon receptor signaling in schizophrenia, and gluconeogenesis/glycolysis in bipolar disorder. Both disorders were characterized by alterations of proteins involved in the oxidative stress response, mitochondrial function, and protein-en...Continue Reading

References

Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·R N Auer
Jul 1, 1998·Biological Psychiatry·F M BenesM S Todtenkopf
Nov 14, 2000·Trends in Neurosciences·W H Gispen, G J Biessels
Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M J van HemertG P van Heusden
Mar 23, 2002·Journal of Neurochemistry·F GardoniM Di Luca
May 15, 2002·European Journal of Pharmacology·Geert Jan BiesselsWillem Hendrik Gispen
Sep 3, 2003·Nature Reviews. Neuroscience·Daniela BergOlaf Riess
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
Mar 7, 2006·Medical Hypotheses·Kiyotoshi Kaneko, Naomi S Hachiya
Jun 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francine M BenesMartin Minns
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J Lodge, Anthony A Grace
Feb 19, 2008·The American Journal of Psychiatry·Takanori HashimotoDavid A Lewis
Oct 17, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C Anthony AltarStephen D Ginsberg
Jan 17, 2009·Neuron·Larry R Squire
Jan 23, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Deepak GroverJames B Potash
Apr 1, 2009·The Journal of Physiology·Catriona M HoustonTrevor G Smart
Apr 15, 2009·Current Opinion in Psychiatry·Alex FornitoChristos Pantelis
Jun 30, 2009·Proteomics·Jane A EnglishDavid R Cotter
Jan 6, 2010·The American Journal of Psychiatry·Abraham ReichenbergTerrie E Moffitt
Jan 15, 2010·Schizophrenia Research·Ian Ellison-Wright, Ed Bullmore
Feb 4, 2010·Archives of General Psychiatry·David C GlahnMichael A Escamilla
Jul 14, 2010·Frontiers in Neuroendocrinology·Jere LindénRaimo Pohjanvirta
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicole GuetgBernhard Bettler
Sep 14, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hayley B ClayChristine Konradi
Sep 28, 2010·Biological Chemistry·Josef Abel, Thomas Haarmann-Stemmann
Oct 5, 2010·Biological Psychiatry·Jane A EnglishDavid R Cotter
Oct 28, 2010·Antioxidants & Redox Signaling·Ravinder Reddy, Rajiv Reddy

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Citations

Mar 15, 2016·Frontiers in Cellular Neuroscience·Juliana S CassoliDaniel Martins-de-Souza
Aug 2, 2015·European Archives of Psychiatry and Clinical Neuroscience·Verônica M Saia-CeredaDaniel Martins-de-Souza
Apr 21, 2016·Schizophrenia Research·Verônica M Saia-CeredaDaniel Martins-de-Souza
Apr 27, 2016·Journal of Proteomics·Jemmyson Romário de JesusMarco Aurélio Zezzi Arruda
Apr 23, 2016·International Journal of Molecular Sciences·Joëlle V F CoumansPierre D J Moens
Jul 6, 2016·European Archives of Psychiatry and Clinical Neuroscience·Verônica M Saia-CeredaJuliana M Nascimento
Aug 30, 2016·Expert Review of Proteomics·Laura GiustiAntonio Lucacchini
Sep 8, 2016·Analytical and Bioanalytical Chemistry·Manveen K Sethi, Joseph Zaia
Jan 18, 2017·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisMichael Berk
May 26, 2017·Expert Review of Proteomics·Enzo ScifoMaciej Lalowski
Jul 15, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kaya K JacobsenJan Haavik
Sep 6, 2017·Expert Review of Proteomics·Madia LozuponeFrancesco Panza
Aug 29, 2018·International Journal of Molecular Sciences·Ludmila Juricek, Xavier Coumoul
Oct 22, 2019·International Journal of Tryptophan Research : IJTR·Stein-Erik Hafstad SolvangLasse Melvaer Giil
Feb 27, 2016·Acta Crystallographica. Section F, Structural Biology Communications·Siti Nurulnabila A RahamanChyan Leong Ng
Oct 26, 2016·Molecular Medicine Reports·Min PangHai-Long Wang
Sep 25, 2017·Frontiers in Neuroscience·Giuliana S ZuccoliDaniel Martins-de-Souza
Oct 4, 2018·PeerJ·Siti Nurulnabila A RahamanChyan Leong Ng
Jul 16, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Jaqueline S GenerosoTatiana Barichello
Dec 17, 2018·Journal of Molecular Neuroscience : MN·Thais Guimarães Martins NeryFabio Passetti
Apr 13, 2021·The FEBS Journal·Jiaxin YangKe Tang
May 7, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·André S L M AntunesDaniel Martins-de-Souza

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