Proteomic profile associated with cell death induced by androgens in Taenia crassiceps cysticerci: proposed interactome

Journal of Helminthology
J AmbrosioJorge Morales-Montor

Abstract

Androgens have been shown to exert a cysticidal effect upon Taenia crassiceps, an experimental model of cysticercosis. To further inquire into this matter, the Taenia crassiceps model was used to evaluate the expression of several proteins after testosterone (T4) and dihydrotestosterone (DHT) in vitro treatment. Under 2-D proteomic maps, parasite extracts were resolved into approximately 130 proteins distributed in a molecular weight range of 10-250 kDa and isoelectrical point range of 3-10. The resultant proteomic pattern was analysed, and significant changes were observed in response to T4 and DHT. Based on our experience with electrophoretic patterns and proteomic maps of cytoskeletal proteins, alteration in the expression of isoforms of actin, tubulin and paramyosin and of other proteins was assessed. Considering that androgens may exert their biological activity in taeniids through the non-specific progesterone receptor membrane component (PGRMC), we harnessed bioinformatics to propose the identity of androgen-regulated proteins and establish their hypothetical physiological role in the parasites. These analyses yield a possible explanation of how androgens exert their cysticidal effects through changes in the expression o...Continue Reading

References

Jun 1, 1972·International Journal for Parasitology·J K SmithR E Kuhn
Dec 1, 1982·International Journal for Parasitology·I Bhai, A K Pandey
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·C LarraldeM C Romano
Apr 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·W R MillerJ Telford
Mar 28, 2002·Physiological Reviews·Volker Gerke, Stephen E Moss
Jul 20, 2002·Experimental Parasitology·J Morales-MontorR T Damian
Sep 28, 2002·International Journal for Parasitology·J Morales-MontorR T Damian
May 27, 2003·Neuroendocrinology·Jingjing Liu Kipp, Victor D Ramirez
Sep 16, 2003·Cell Biology International·Javier R AmbrosioAna Flisser
Apr 5, 2005·Microbes and Infection·José A Vargas-VillavicencioJorge Morales-Montor
Oct 21, 2005·Trends in Parasitology·Galileo EscobedoJorge Morales-Montor
Nov 14, 2006·Parasite Immunology·J A Vargas-VillavicencioJ Morales-Montor
Jan 24, 2007·Trends in Parasitology·Luis I AlvarezCarlos E Lanusse
Aug 4, 2009·Parasites & Vectors·Carolina R AlmeidaEmmanuel Dias-Neto
May 27, 2010·Journal of Cell Science·Diane ColelloSusan E LaFlamme
Dec 1, 2010·The Journal of Biological Chemistry·Jaime MelendezYi Zheng
May 31, 2011·Steroids·Elizabeth Guadalupe Ibarra-CoronadoJorge Morales-Montor
Nov 24, 2011·International Journal of Biological Sciences·Galileo EscobedoJorge Morales-Montor
Jan 21, 2012·Molecular and Biochemical Parasitology·Veridiana G VirginioHenrique B Ferreira
Mar 15, 2013·Nature·Isheng J TsaiMatthew Berriman
May 3, 2013·Molecular Cancer Therapeutics·Sucharita J Mistry, William K Oh
Mar 13, 2014·Cytoskeleton·Christos StournarasFlorian Lang
Mar 22, 2014·Parasitology Research·Olivia Reynoso-DucoingJavier R Ambrosio
Jun 1, 2014·International Journal for Parasitology·Javier R AmbrosioJorge Morales-Montor
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Si YanTatyana Polenova

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