Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals

Reproductive Biology and Endocrinology : RB&E
Xiaodan CaoRenxiong Wei

Abstract

Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospermia. The reduction of sperm motility in asthenozoospermic patients had been attributed to factors, for instance, energy metabolism dysfunction or structural defects in the sperm-tail protein components and the differential proteins potentially involved in sperm motility such as COX6B, ODF, TUBB2B were described. Comparative proteomic analysis open a window to discover the potential pathogenic mechanisms of asthenozoospermia and the biomarkers with clinical significance.

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Citations

Jun 30, 2019·Journal of Assisted Reproduction and Genetics·Yuewen Zhao, Frederick W K Kan
Aug 6, 2020·Frontiers in Endocrinology·Francesco ManfrevolaRosanna Chianese
Jun 30, 2019·International Journal of Molecular Sciences·Natalina MoscatelliAlessandra Ferramosca
Feb 16, 2019·International Journal of Molecular Sciences·Manesh Kumar Panner SelvamPeter N Pushparaj
Dec 15, 2020·Lancet·Ashok AgarwalRupin Shah
Jul 1, 2020·Andrologia·Manesh Kumar Panner SelvamRalf Henkel
Mar 26, 2021·Frontiers in Cell and Developmental Biology·Meimei ZhengHui Zhu
Apr 9, 2021·Reproduction in Domestic Animals = Zuchthygiene·Rongala LaxmivandanaSoumen Naskar
Sep 29, 2021·Molecular Human Reproduction·Farners AmargantIsabelle Vernos

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Methods Mentioned

BETA
density gradients centrifugation
electrophoresis

Software Mentioned

MADLI
DA
OPLS
Ingenuity Pathways Analysis
- Plot )

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