Proteomic profiling of cancer--opportunities, challenges, and context

The Journal of Pathology
David Arnott, Michael R Emmert-Buck

Abstract

The article by Roesch-Ely and colleagues in a recent issue of The Journal of Pathology describes the use of proteomic techniques to examine mucosal biopsies in patients with head and neck squamous cell cancer (HNSCC) and in corresponding control samples. The authors were able to determine the anatomical site of origin of the biopsies based on modelling of multiplex protein datasets, and to use the information to analyse field cancerization as a means of predicting tumour recurrence. Although the study included only a relatively small number of cases, and will require future validation in a larger patient cohort, the results point to the potential of proteomics to increase our understanding of cancer biology, and in this instance to offer clinical value.

References

Feb 28, 2002·Lancet·Emanuel F PetricoinLance A Liotta
Sep 6, 2002·The American Journal of Pathology·Maarten P TaborBoudewijn J M Braakhuis
Dec 19, 2002·Molecular & Cellular Proteomics : MCP·N Leigh Anderson, Norman G Anderson
Jun 11, 2003·BMC Bioinformatics·James M Sorace, Min Zhan
Jan 18, 2005·Seminars in Cancer Biology·Boudewijn J M BraakhuisRuud H Brakenhoff
Jan 29, 2005·Molecular & Cellular Proteomics : MCP·Robert L Caldwell, Richard M Caprioli
Jul 16, 2005·Molecular & Cellular Proteomics : MCP·N Leigh Anderson
Dec 8, 2005·Molecular & Cellular Proteomics : MCP·Leigh Anderson, Christie L Hunter
Feb 10, 2007·Expert Review of Proteomics·Terence C W Poon
Sep 26, 2007·Expert Review of Molecular Diagnostics·Amy VanMeterEmanuel F Petricoin
Apr 4, 2008·Nature·Samir M HanashVitor M Faca
May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert E GersztenLorraine B Ware
Jul 3, 2008·Advances in Experimental Medicine and Biology·Runa SpeerEmanuel F Petricoin
Dec 2, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Neil R KitteringhamB Kevin Park
Dec 26, 2008·Briefings in Functional Genomics & Proteomics·Xiaoying YeTimothy D Veenstra
Mar 11, 2009·Briefings in Functional Genomics & Proteomics·Nagathihalli S Nagaraj
Apr 24, 2009·Expert Review of Proteomics·Sze Chuen Cesar WongAnthony Tak Cheung Chan
May 2, 2009·Biochimica Et Biophysica Acta·Michael A Tainsky
May 12, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G Ulrich-MerzenichH Vetter
May 19, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Peter Findeisen, Michael Neumaier
Jun 9, 2009·Cancer Biology & Therapy·Pei WangAmanda G Paulovich
Aug 20, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa H CazaresO John Semmes
Sep 8, 2009·Expert Review of Molecular Diagnostics·Jerzy Ostrowski, Lucjan S Wyrwicz
Oct 15, 2009·The Cancer Journal·Daniel S W TanPaul Workman
Dec 5, 2009·The Journal of Pathology·Peter A HallRichard Poulsom
Dec 31, 2009·Clinical Chemistry·David F Ransohoff
Feb 9, 2010·Journal of Proteomics·Tieneke B M Schaaij-VisserMonique Slijper
Mar 25, 2010·Cancer Research·Kaushal Parikh, Maikel P Peppelenbosch
Apr 3, 2010·Trends in Biotechnology·Pierre LescuyerDenis F Hochstrasser
Jul 2, 2010·The Journal of Pathology·Mariana Roesch-ElyFranz X Bosch

❮ Previous
Next ❯

Citations

Apr 18, 2019·Journal of Cancer Prevention·Werissaw HaileselassieWajana Lako Labisso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.