Proteomic response of Streptococcus pneumoniae to iron limitation

International Journal of Medical Microbiology : IJMM
Juliane HoyerDörte Becher

Abstract

Iron is an essential trace element and involved in various key metabolic pathways in bacterial lifestyle. Within the human host, iron is extremely limited. Hence, the ability of bacteria to acquire iron from the environment is critical for a successful infection. Streptococcus pneumoniae (the pneumococcus) is a human pathobiont colonizing symptomless the human respiratory tract, but can also cause various local and invasive infections. To survive and proliferate pneumococci have therefore to adapt their metabolism and virulence factor repertoire to different host compartments. In this study, the response of S. pneumoniae to iron limitation as infection-relevant condition was investigated on the proteome level. The iron limitation was induced by application of the iron chelator 2,2'-bipyridine (BIP) in two different media mimicking different physiological traits. Under these conditions, the influence of the initial iron concentration on pneumococcal protein expression in response to limited iron availability was analyzed. Interestingly, one major difference between these two iron limitation experiments is the regulation of proteins involved in pneumococcal pathogenesis. In iron-poor medium several proteins of this group were dow...Continue Reading

Citations

Jun 20, 2018·PeerJ·Irene Jiménez-MunguíaManuel J Rodríguez-Ortega
Mar 27, 2020·The Journal of Antibiotics·Anne LeonardKaren Methling
Sep 23, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth PerezSuzanne M Cloonan
Oct 1, 2020·Pharmaceuticals·Ravneet ChhabraMeera Nanjundan
Apr 10, 2021·Frontiers in Cellular and Infection Microbiology·Yamil Sanchez-Rosario, Michael D L Johnson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.