Proteomic studies of common chronic pain conditions - a systematic review and associated network analyses.

Expert Review of Proteomics
Björn Gerdle, Bijar Ghafouri

Abstract

The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches in three databases identified 96 studies from PubMed, 161 from Scopus and 155 from Web of Science database. Finally, 27 relevant articles were included. Network analyses based on the identified proteins were performed. Small pain cohorts were investigated and the number of studies per diagnosis and tissue is small. The use of proteomics in chronic pain research is exploratory and larger proteomic studies are needed. It will be necessary to standardize the descriptions of the pain cohorts investigated. There is a need to identify the mechanisms underlying the whole clinical presentation of specific chronic pain conditions. Multivariate methods capable of handling and identifying intercorrelated protein patterns must be applied. Rather than focusing on a few proteins, future studies should use network analyses to investigate interactions and biological processes. Proteomics in combination with bioinformatics have a huge potential to identify pr...Continue Reading

References

Dec 1, 1995·Scientific American·D J Chalmers
Feb 5, 1998·Journal of Mass Spectrometry : JMS·J R Yates
Feb 22, 2001·Science·J C VenterX Zhu
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
May 1, 2002·Electrophoresis·Xianglin YuanDominic M Desiderio
Mar 1, 2003·Nature Biotechnology·Matthias Mann, Ole N Jensen
Mar 14, 2003·Nature·Ruedi Aebersold, Matthias Mann
Jul 7, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·René FejerJan Hartvigsen
Jul 14, 2005·Disability and Rehabilitation·C M HenrikssonB Gerdle
Aug 13, 2005·European Journal of Pain : EJP·Harald BreivikDerek Gallacher
Jul 3, 2007·AIDS Research and Human Retroviruses·Bryan LauRichard D Moore
Jul 17, 2008·BMC Musculoskeletal Disorders·Björn GerdleAnn Bengtsson
May 5, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roger B FillingimJoseph L Riley
Nov 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rea Rodriguez-RaeckeArne May
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Oct 12, 2010·Journal of Neuroscience Research·Danielle L PeterselRaymond Cheung
Oct 28, 2010·Current Opinion in HIV and AIDS·Kyle Strimbu, Jorge A Tavel
Dec 8, 2010·Proteomics. Clinical Applications·Laura BazzichiAntonio Lucacchini
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David A SeminowiczLaura S Stone
May 20, 2011·Nature·Björn SchwanhäusserMatthias Selbach
Jun 28, 2011·Lancet·Dennis C TurkAlex Cahana
Oct 8, 2011·Journal of Proteome Research·Thorsten MüllerKatrin Marcus
Dec 24, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Douglas E HenryWeibin Yang
Apr 17, 2012·Brain Research·Massieh MoayediKaren D Davis
Sep 29, 2012·Clinical Chemistry·Maria P PavlouIvan M Blasutig
Oct 10, 2012·Arthritis and Rheumatism·Kristine Phillips, Daniel J Clauw
Nov 13, 2012·Current Opinion in Biotechnology·Michael R Hoopmann, Robert L Moritz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Breast Cancer Research and Treatment
Sebastian M JudMayada R Bani
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Neonatology Branch of Chinese Medical Association, Editorial Board of Chinese Journal of Contemporary Pediatrics
© 2021 Meta ULC. All rights reserved