PMID: 15354021Sep 9, 2004Paper

Proteomics: a primer for otologists

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
John F McGuire, Begona Casado

Abstract

On July 9, 2003, the National Institutes of Health (NIH) released a new program announcement entitled "Proteomics in Auditory and Developmental Disease Processes." This initiative makes it clear that proteomic analysis in otology is a multi-year research priority for the NIH. The goal of this article is to describe the mechanics of modern proteomic techniques and review their applications in otology to date. General articles from the proteomic literature were used to construct a review of modern proteomic techniques. For literature on proteomics in otology, MEDLINE and CRISP databases were searched by various topics in otology and cross-referenced with principle proteomic technologies. The criterion for selection was any study in otology that employs proteomic technology. Incredible progress has been made in proteomic technology. However, modern proteomic techniques are currently underutilized in otologic research. The NIH proteomics initiative referenced above, in combination with an understanding of the basic tools of modern proteomic science, should help motivate otologists to discover innovative ways to apply modern proteomic techniques to specific problems in otology.

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Citations

Apr 8, 2006·Brain Research·Qing Yin ZhengKumar N Alagramam
Mar 17, 2006·Brain Research·Isolde Thalmann
Mar 22, 2015·Expert Review of Proteomics·Ali AlawiehMarc Bassim

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