PMID: 20118634Feb 2, 2010Paper

Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor alpha (PPARalpha) stimulation

The Journal of Toxicological Sciences
Masafumi MiyazakiMatthew P Patricelli

Abstract

To investigate peroxisomal proliferator-activated receptor alpha (PPARalpha) signal responses in heart muscle, we performed LC-MS/MS-based proteomics analysis of heart muscle from rats given fenofibrate or clofibrate. Fenofibrate increased the expression of ACAA2, DECR1, and ECH1 consistent with activation of PPARalpha. Fenofibrate and clofibrate reduced the expression of 10 and 12 proteins, respectively with the expression of ACSL1, SLC25A4, A1BG, HADHA, ATP2A2, BDH1, ETFDH, HADHB, and CPT2 being reduced in common with both of fibrate-treated groups. The approach adopted in this study provides an efficient method for monitoring global changes in protein expression.

References

Oct 1, 1992·Physiological Reviews·G J van der VusseR S Reneman
Feb 5, 2004·Journal of the American Chemical Society·Gregory C AdamBenjamin F Cravatt
Mar 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eric S OkerbergMatthew P Patricelli
Feb 14, 2006·Proteomics·Jean-François LéonardJean-Charles Gautier

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Citations

Nov 16, 2012·PloS One·Miguel A LanaspaRichard J Johnson
Sep 10, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Weidong XieLijun Du
Aug 8, 2015·Journal of Atherosclerosis and Thrombosis·Takefumi Doi
Feb 16, 2012·Cell Cycle·Shin-ichi OkaJunichi Sadoshima
Jan 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Xiaoxiang MaoKai Huang
Jun 18, 2015·Cardiovascular Toxicology·Mahdieh RahmatollahiAhmad Reza Dehpour

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