Proteomics analysis of human umbilical vein endothelial cells treated with resveratrol

Amino Acids
Bin ShaoYuquan Wei

Abstract

In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous age-related chronic diseases, including cardiovascular atherosclerosis, cancer, hypertension, and diabetes, but the biological processes and molecular pathways by which resveratrol induces these beneficial effects, as well as its safety and toxicology remain largely undefined. To explore the molecular mechanisms of resveratrol involved in the amelioration of endothelial dysfunction and vascular disease, in the present study the protein profile changes of human umbilical vein endothelial cells in response to resveratrol treatment were investigated using proteomics approaches (2-DE combined with MS/MS). As a result, four down-regulated protein species named elongation factor 2 (EEF2), carboxymethyl-cofilin-1 (cofilin-1), acetyl-eukaryotic translation initiation factor 5A-1 (acetyl-EIF5A) and barrier-to-autointegration factor, and five up-regulated protein species named heat shock protein beta-1 (HSP27), phospho-HSP27, phospho-stathmin, Nicotinate-nucleotide pyrophosphorylase and 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase were identified. Among them, two translation-re...Continue Reading

References

Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sheng-Hong TsengYun Chen
Sep 8, 2004·Biochemistry·Leonid BuryanovskyyZhongtao Zhang
Sep 16, 2004·Journal of Cellular Biochemistry·Camelia Iancu Rubin, George F Atweh
Sep 13, 2005·Nature Structural & Molecular Biology·Christina Marchetti BradleyFred Dyda
Jan 13, 2006·Trends in Biochemical Sciences·Bénédicte Van MaeleZeger Debyser
Apr 22, 2006·The Biochemical Journal·Jiandi Zhang
Aug 1, 2006·International Journal of Experimental Pathology·Gordon FernsShahida Shafi
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Jan 9, 2007·Trends in Molecular Medicine·Danica Chen, Leonard Guarente
Jan 11, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Isamu GotohMotoharu Seiki
Apr 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariAnna Csiszar
Apr 26, 2007·Molecular Endocrinology·Hiroyasu YamamotoJohan Auwerx
Jun 27, 2007·Cancer Chemotherapy and Pharmacology·Aiping TongYuquan Wei
Mar 19, 2008·Trends in Cell Biology·Nektarios Tavernarakis
Apr 17, 2008·Cell Cycle·Kuzhuvelil B Harikumar, Bharat B Aggarwal
Jul 22, 2008·Chemistry Central Journal·Peter R JungblutHartmut Schlüter
Oct 28, 2008·Journal of Lipid Research·Carol A Rouzer, Lawrence J Marnett
Jan 20, 2009·Current Pharmaceutical Design·Nica M Borradaile, J Geoffrey Pickering
Apr 22, 2009·Biochemical and Biophysical Research Communications·Seung Bum LeeMyung Hee Park
May 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Anna CsiszarZoltan Ungvari
Jul 14, 2009·Cellular and Molecular Life Sciences : CMLS·Sergiy Kostenko, Ugo Moens
Sep 15, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariAnna Csiszar
Sep 22, 2009·Cellular Signalling·Myung-Ja LeeBalakuntalam S Kasinath
Oct 22, 2009·Chemical Biology & Drug Design·Dirk BeherMinghan Wang
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Brett LomenickJing Huang
Jan 12, 2010·The Journal of Biological Chemistry·Michelle PacholecKay Ahn
Jun 12, 2010·Annals of the New York Academy of Sciences·Bindi M DoshiJuliet Lee
Jun 29, 2010·Cell Cycle·Cristina CapanniGiovanna Lattanzi
Dec 17, 2010·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jun 21, 2011·Molecular Nutrition & Food Research·James M SmoligaHeather A Hausenblas
Jul 5, 2011·Biophysical Journal·Brannon R McCulloughEnrique M De La Cruz
Jul 7, 2011·The Biochemical Journal·Luis F de FigueiredoStefan Schuster
Jul 14, 2011·Biochimica Et Biophysica Acta·Vernon W Dolinsky, Jason R B Dyck

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