Proteomics analysis of Xenopus laevis gonad tissue following chronic exposure to atrazine

Environmental Toxicology and Chemistry
Xiuping ChenYufa Peng

Abstract

Atrazine is the most commonly detected pesticide contaminant in ground and surface water. Previous studies have shown that atrazine is an endocrine disruptor owing to its adverse effects on the male reproductive system in several vertebrates, but very few molecular mechanisms for these effects have been revealed. In the present study, Xenopus laevis were exposed to 100 ppb of atrazine for 120 d, and then the isobaric tags for relative and absolute quantitation (iTRAQ) technique was used to detect global changes in protein profiles of the testes and ovaries. The results showed that 100 ppb of atrazine exposure adversely affected the growth of X. laevis and did not induce hermaphroditism but delayed or prevented the development of male seminiferous tubules. Proteomic analysis showed that atrazine altered expression of 143 and 121 proteins in the testes and ovaries, respectively, and most of them are involved in cellular and metabolic processes and biological regulation based on their biological processes. In addition, apoptosis, tight junctions, and metabolic pathways were significantly altered in the atrazine-treated gonads. Based on the above results, it is postulated that the reproductive toxicity of atrazine may be the result...Continue Reading

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Citations

Jan 18, 2017·Genesis : the Journal of Genetics and Development·Amy K Sater, Sally A Moody
Feb 11, 2018·Environmental Toxicology·Heng-Dao LinSsu-Ching Chen
Jan 2, 2021·Environmental Pollution·Wadson Rodrigues RezendeClassius De Oliveira
Mar 7, 2021·International Journal of Environmental Research and Public Health·Mar Requena-MullorRaquel Alarcon-Rodriguez

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