Proteomics and breast cancer: new perspectives and limitations

Pathologie-biologie
Hubert Hondermarck

Abstract

From differential analysis for the identification of biomarkers, to functional analysis for the evidencing of new therapeutic targets, proteomics brings new comprehensive information for a better understanding of the molecular basis of oncology and new perspectives for the clinic. However the major limitation of proteomic investigations and more generally of post-genomic approaches remains the molecular and cellular complexity of biological systems. This will be illustrated with the case of breast cancer.

References

Mar 14, 2003·Nature·Ruedi Aebersold, Matthias Mann
May 31, 2003·Molecular & Cellular Proteomics : MCP·Hubert Hondermarck
Aug 29, 2003·Oncogene·Laurent DolléHubert Hondermarck
Jan 23, 2004·Nature Reviews. Cancer·Heiko Hermeking
Aug 3, 2004·Nature Reviews. Cancer·Samir Hanash

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Citations

Feb 13, 2009·Proteomics·Luke MacAleeseRon M A Heeren
Jan 1, 2008·Proteomics. Clinical Applications·Serhiy Souchelnytskyi, Louise Alldridge

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