Proteomics and the blood-brain barrier: how recent findings help drug development

Expert Review of Proteomics
Yannis Karamanos, Gwënaël Pottiez

Abstract

The drug discovery and development processes are divided into different stages separated by milestones to indicate that significant progress has been made and that certain criteria for target validation, hits, leads and candidate drugs have been met. Proteomics is a promising approach for the identification of protein targets and biochemical pathways involved in disease process and thus plays an important role in several stages of the drug development. The blood-brain barrier is considered as a major bottleneck when trying to target new compounds to treat neurodegenerative diseases. Based on the survey of recent findings and with a projection on expected improvements, this report attempt to address how proteomics participates in drug development.

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Citations

Apr 5, 2020·Cells·Julien Saint-PolYannis Karamanos
Dec 19, 2020·Pharmaceutics·Seigo Kimura, Hideyoshi Harashima
Jul 14, 2021·Journal of Biomedical Research·Gradimir Misevic
Jul 22, 2017·Molecular Pharmaceutics·Zhijiang ChenXingguo Mei

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