PMID: 11909689Mar 23, 2002Paper

Proteomics in experimental gerontology

Experimental Gerontology
Jean-François DierickOlivier Toussaint

Abstract

The first gerontological studies using two-dimensional gel electrophoresis (2DGE) were frustrating since it was very difficult, when not impossible, to identify the proteins for which an age-related change in expression level was suspected. Reproducibility was also a main pitfall. Accumulated progress in 2DGE and especially the development of mass spectrometry of proteins and peptides gave accessibility to the routine identification of differentially expressed proteins. A new paradigm was born: proteomics. In addition to expression changes, post-translational modifications are included in proteomics, and will be more and more studied using mass spectrometry. After a review of the current developments of 2DGE and mass spectrometry, we shall discuss how the technologies currently available in proteomics could give fresh impetus to experimental gerontology, complementary to more recent approaches based on wide expression analysis tools such as DNA and protein arrays.

References

Sep 1, 1979·Mechanisms of Ageing and Development·T Schmidt, G T Baker
Jan 1, 1978·Gerontology·D L WilsonG C Stone
Sep 1, 1990·Differentiation; Research in Biological Diversity·S T NikkariO Jaakkola
Sep 1, 1989·Acta Physiologica Scandinavica·H KlitgaardE Damiani
Dec 1, 1989·Mechanisms of Ageing and Development·A R HeydariA Richardson
Oct 5, 1989·Molecular and Cellular Biochemistry·V RussanovaR Tsanev
Jan 1, 1988·Journal of Cell Science. Supplement·K BayreutherK Maier
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K BayreutherP I Francz
Jul 1, 1987·The Biochemical Journal·L A MeheusJ R Vanfleteren
Mar 1, 1986·Mechanisms of Ageing and Development·J E FlemingK G Bensch
May 31, 1985·Mechanisms of Ageing and Development·T E Johnson, G McCaffrey
Jan 1, 1985·Advances in Experimental Medicine and Biology·S GoldsteinC P Stanners
Jun 22, 1973·Nature·L E Orgel
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M M Kay
Jun 29, 1984·Biochimica Et Biophysica Acta·F C RamaekersH Bloemendal
Jun 1, 1981·Mechanisms of Ageing and Development·J ParkerJ Gallant
Apr 1, 1983·Revue française de transfusion et immuno-hématologie·A LefèvreM Goudemand
Sep 1, 1982·Journal of Biochemical and Biophysical Methods·B BjellqvistW Postel
Nov 15, 1982·European Journal of Biochemistry·F RamaekersH Bloemendal
Aug 6, 1981·Nature·B F Clark
May 1, 1993·Molecular and Cellular Biology·A R HeydariA Richardson
Apr 1, 1995·Experimental Cell Research·K S Kulju, J M Lehman
Mar 1, 1994·Experimental Gerontology·R T Dell'Orco, W L Whittle
Nov 15, 1993·Biochemical and Biophysical Research Communications·E P Rogakou, K E Sekeri-Pataryas
Jul 1, 1993·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·H MinamiO Yahara
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J HenzelC Watanabe
Oct 1, 1996·Aging : Clinical and Experimental Research·J L PipkinD A Casciano
Jul 1, 1997·Mechanisms of Ageing and Development·J L PipkinD A Casciano

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Citations

Dec 31, 2003·Experimental Gerontology·Olivier Toussaint
May 14, 2003·Experimental Gerontology·Christian Schöneich
Jun 5, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Wen ChenBinggen Ru
Aug 19, 2007·Microbial Cell Factories·Robert Lj GrahamGeoff McMullan
Jul 13, 2004·Annals of the New York Academy of Sciences·Sylvie PoggioliBertrand Friguet
Jun 9, 2004·Clinics in Geriatric Medicine·H Fai PoonD Allan Butterfield
Aug 4, 2004·Experimental Gerontology·Chul Hong KimHae Young Chung
Oct 21, 2004·Mass Spectrometry Reviews·Christian Schöneich
Apr 12, 2007·Expert Review of Proteomics·Victor S Sharov, Christian Schöneich
Jul 31, 2013·Proteomics·Julia Christin KortBettina Siebers
Mar 27, 2020·Journal of Basic Microbiology·Chellaiah Shiny MatildaChittibabu Shanthi

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