Proteomics in Rheumatoid Arthritis Research

Immune Network
Yune-Jung ParkWan-Uk Kim

Abstract

Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the large-scale study of the proteome, has emerged as a powerful technique for protein identification and characterization. For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.

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Citations

Dec 9, 2015·International Journal of Rheumatic Diseases·Jayakanthan KabeerdossDebashish Danda
Sep 4, 2016·The International Journal of Biochemistry & Cell Biology·Daniela BraconiAnnalisa Santucci
Jan 17, 2017·Scientific Reports·Stefan SiebertIain McInnes
Aug 25, 2020·International Journal of Rheumatology·Abeer A AbdelatiRasha A Ghazala
May 12, 2017·Rheumatology International·Xinqiang Song, Qingsong Lin
Feb 26, 2019·Frontiers in Immunology·Maria PapadakiEleni Douni
Aug 10, 2020·Journal of Proteomics·Elisabetta ChiaradiaBerta Cillero-Pastor
Oct 3, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pei HeFei-Yan Deng
Nov 6, 2021·Experimental and Therapeutic Medicine·Dong-Sik ChaeJun Sik Lee

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Methods Mentioned

BETA
chip
two-hybrid
biopsy
immunoprecipitation
tandem
electrophoresis

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