Proteomics: recent applications and new technologies

Basic & Clinical Pharmacology & Toxicology
Mollisa M ElrickDavid C Thompson

Abstract

Interest in proteomics as a tool for drug development and a myriad of other applications continues to expand at a rapid rate. Proteomic analyses have recently been conducted on tissues, biofluids, subcellular components and enzymatic pathways as well as various disease and toxicological states, in both animal models and man. In addition, several recent studies have attempted to integrate proteomics data with genomics and/or metabonomics data in a systems biology approach. The translation of proteomic technology and bioinformatics tools to clinical samples, such as in the areas of disease and toxicity biomarkers, represents one of the major opportunities and challenges facing this field. An ongoing challenge in proteomics continues to be the analysis of the serum proteome due to the vast number and complexity of proteins estimated to be present in this biofluid. Aside from the removal of the most abundant proteins, a number of interesting approaches have recently been suggested that may help reduce the overall complexity of serum analysis. In keeping with the increasing interest in applications of proteomics, the tools available for proteomic analyses continue to improve and expand. For example, enhanced tools (such as software ...Continue Reading

References

Feb 28, 2002·Lancet·Emanuel F PetricoinLance A Liotta
Jul 2, 2002·Nature Biotechnology·Gregory C AdamBenjamin F Cravatt
Mar 12, 2003·Biochemical Pharmacology·Wilbert H M HeijneBen van Ommen
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Leonard J FosterMatthias Mann
May 13, 2003·Nature Biotechnology·Donmienne LeungBenjamin F Cravatt
Aug 2, 2003·Breast Cancer Research and Treatment·Susan M VarnumRichard C Zangar
Jan 14, 2004·Molecular & Cellular Proteomics : MCP·N Leigh AndersonAnna Lobley
Jan 20, 2004·Trends in Cell Biology·Amos BaruchMatthew Bogyo
Mar 5, 2004·Proteomics·Chris BockDominic Zichi
Apr 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jose M SilvaGregory J Hannon
May 8, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ji GaoDonna M Dambach
May 13, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Henry E Neuman de Vegvar, William H Robinson
May 18, 2004·Chemical Research in Toxicology·Georgina Meneses-LorenteAlan Watt
May 29, 2004·Analytical Chemistry·Cagri A SavranScott R Manalis
Jun 3, 2004·Electrophoresis·Ming ZhouThomas P Conrads
Jun 19, 2004·American Journal of Nephrology·Visith Thongboonkerd
Jun 29, 2004·The Journal of Biological Chemistry·Lujian LiaoJunmin Peng
Jun 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alan SaghatelianBenjamin F Cravatt
Jul 1, 2004·Expert Review of Molecular Diagnostics·Christian Harwanegg, Reinhard Hiller
Sep 17, 2004·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·T G KlenøU G Sidelmann
Sep 29, 2004·Current Opinion in Chemical Biology·Dal-Hee Min, Milan Mrksich
Oct 8, 2004·Nature Biotechnology·Eugene C ButcherEric J Kunkel
Nov 13, 2004·Proteomics·Richard Barry, Mikhail Soloviev
Nov 27, 2004·Electrophoresis·György A Marko-VargaThomas Laurell
Dec 2, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Günter Mayer, Andreas Jenne
Dec 8, 2004·Toxicologic Pathology·Barbara A Wetmore, B Alex Merrick
Dec 17, 2004·Analytical and Bioanalytical Chemistry·Michael W Linscheid
Dec 22, 2004·The Journal of Physiology·Leigh Anderson
Jan 15, 2005·Analytical Chemistry·Jacques ColingeLydie Bougueleret
Jan 18, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Alicia B BergerMatthew Bogyo
Jan 25, 2005·Molecular and Cellular Endocrinology·Zhen XiaoHaleem J Issaq
Feb 1, 2005·FEBS Letters·Katheryn A Resing, Natalie G Ahn
Feb 11, 2005·Current Opinion in Chemical Biology·Joshua LaBaer, Niroshan Ramachandran
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Eric T FungScot R Weinberger
Feb 23, 2005·Molecular & Cellular Proteomics : MCP·Henrik MolinaAkhilesh Pandey

❮ Previous
Next ❯

Citations

Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Karen P Phillips, Warren G Foster
Dec 17, 2014·Bioanalysis·Lasse Jørgensen CehofskiHenrik Vorum
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Frédéric FournierDavid R Klug
Feb 2, 2008·Toxicology·Fitz B Collings, Vishal S Vaidya
Jun 19, 2007·Trends in Cardiovascular Medicine·Willem E HellingsGerard Pasterkamp
Nov 23, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Anna Bodzon-KulakowskaJerzy Silberring
Sep 1, 2007·Proteomics. Clinical Applications·Marta Lomnytska, Serhiy Souchelnytskyi
Dec 1, 2007·Proteomics. Clinical Applications·Yue GeRussell D Owen
Oct 1, 2008·Proteomics. Clinical Applications·Xia Xu, Timothy D Veenstra
May 26, 2007·The Journal of Pharmacy and Pharmacology·Fleur L MoseleyGavin Brooks
Sep 1, 2007·Proteomics. Clinical Applications·Philip DoranKay Ohlendieck
Mar 19, 2009·Mass Spectrometry Reviews·Yie Hou LeeMaxey C M Chung
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Bruno L FerreiraHelena C Castro
Dec 14, 2011·Journal of Proteomics·Carolin HuhnAndré M Deelder
Apr 4, 2009·FEMS Yeast Research·Alexandra GrafDiethard Mattanovich
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lyndsay HarrisUNKNOWN American Society of Clinical Oncology
Sep 27, 2007·Lab on a Chip·Philip S Waggoner, Harold G Craighead
Jul 18, 2008·Molecular BioSystems·Visith Thongboonkerd
Sep 16, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephen W Edwards, R Julian Preston
Dec 17, 2010·World Journal of Hepatology·Maria PleguezueloManuel de la Mata
Jun 10, 2008·Journal of Animal Science·J D Lippolis, T A Reinhardt
Jul 20, 2007·Chemical Reviews·Haleem J IssaqTimothy D Veenstra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.