Proteomics Reveals Profound Metabolic Changes in the Alcohol Use Disorder Brain

ACS Chemical Neuroscience
Charmaine EnculescuBenjamin L Schulz

Abstract

Changes in brain metabolism are a hallmark of alcohol use disorder (AUD). Determining how AUD changes the brain proteome is critical for understanding the effects of alcohol consumption on biochemical processes in the brain. We used data-independent acquisition mass spectrometry proteomics to study differences in the abundance of proteins associated with AUD in prefrontal lobe and motor cortex from autopsy brain. AUD had a substantial effect on the overall brain proteome exceeding the inherent differences between brain regions. Proteins associated with glycolysis, trafficking, the cytoskeleton, and excitotoxicity were altered in abundance in AUD. We observed extensive changes in the abundance of key metabolic enzymes, consistent with a switch from glucose to acetate utilization in the AUD brain. We propose that metabolic adaptations allowing efficient acetate utilization contribute to ethanol dependence in AUD.

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Citations

Sep 17, 2020·International Journal of Molecular Sciences·Daniel R LathenAdrian Rothenfluh
Aug 7, 2019·Alcoholism, Clinical and Experimental Research·Jody TanabeBoris Tabakoff
Mar 9, 2021·Alcoholism, Clinical and Experimental Research·Jody TanabeEllen L Burnham
Jul 11, 2021·Communications Biology·Hugo D PerdomoSassan Asgari

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