Proteomics studies in inner ear disorders: pathophysiology and biomarkers

Expert Review of Proteomics
Ali AlawiehMarc Bassim

Abstract

Although proteomics has been exploited in a wide range of diseases for identification of biomarkers and pathophysiological mechanisms, there are still biomedical disciplines such as otology where proteomics platforms are underused due to technical challenges and/or complex features of the disease. Thus, in the past few years, healthcare and scientific agencies have advocated the development and adoption of proteomic technologies in otological research. However, few studies have been conducted and limited literature is available in this area. Here, we present the state of the art of proteomics in otology, discussing the substantial evidence from recent experimental models and clinical studies in inner-ear conditions. We also delineate a series of critical issues including minute size of the inner ear, delicacy and poor accessibility of tissue that researchers face while undertaking otology proteomics research. Furthermore, we provide perspective to enhance the impact and lead to the clinical implementation of these proteomics-based strategies.

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Citations

Nov 24, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sofia WaissbluthSam J Daniel
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Oct 18, 2019·Frontiers in Neurology·Luis LassalettaVictor Martinez-Glez
Oct 26, 2021·Ear, Nose, & Throat Journal·Ruwaa SamarraiKourosh Parham

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