Proteomics urine analysis of pregnant women suffering from multiple sclerosis

Journal of Proteome Research
Vaibhav SinghTheo M Luider

Abstract

Multiple sclerosis (MScl) frequently is remitted during the third trimester of pregnancy but exacerbated in the first postpartum period. In this context, we investigated protein identification, its abundance, and its change in urine related to these two periods. Using mass spectrometry (LTQ Orbitrap), we identified 1699 tryptic peptides (related to 402 proteins) in urine from 31 MScl and 8 control at these two periods. Pregnancy-related peptides were significantly elevated (p < 0.01) in MScl patients compared with controls (Analysis 1: 531 peptides in MScl and 36 peptides in controls higher abundant in the third trimester compared to postpartum). When comparing the longitudinal differences (Analysis 2), we identified 43 (related to 35 proteins) MScl disease-associated peptides (p < 0.01) with increased or decreased difference ratio in MScl compared with controls. The most discriminating peptides identified were trefoil factor 3 and lysosomal-associated membrane protein 2. Both proteins have a role in the innate immune system. Three proteins with a significant decreased ratio were plasma glutamate carboxypeptidase, Ig mu chain C region, and osteoclast associated immune like receptor. Our results indicate that the protein express...Continue Reading

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Citations

Jan 14, 2016·Journal of Proteome Research·Teklab GebregiworgisRobert Powers
Jan 12, 2016·Genomics, Proteomics & Bioinformatics·Manxia An, Youhe Gao
Apr 12, 2016·Proteomics. Clinical Applications·Piero Del BoccioDamiana Pieragostino
Nov 8, 2018·Disease Markers·Maria Luisa TatarannoManon J N L Benders
Oct 30, 2020·Frontiers in Immunology·Monokesh K SenDavid A Mahns
May 4, 2021·Talanta·Maria AntónioAna L Daniel-da-Silva
May 22, 2021·Biomarker Insights·Ameneh JafariMostafa Rezaei-Tavirani
Jul 25, 2021·International Journal of Molecular Sciences·Monokesh K SenJens R Coorssen

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