Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing

Development
MaryJane ShimellNuria M Romero

Abstract

Adult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila, growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Here, we test this by examining the consequences of null mutations in the Ptth gene for Drosophila development. Loss of Ptth causes several developmental defects, including a delay in developmental timing, increase in critical weight, loss of coordination between body and imaginal disc growth, and reduced adult survival in suboptimal environmental conditions such as nutritional deprivation or high population density. These defects are caused by a decrease in ecdysone production associated with altered transcription of ecdysone biosynthetic genes. Therefore, the PTTH signal contributes to coordination between environmental cues and the developmental program to ensure individual fitness and survival.

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Citations

Feb 20, 2020·International Journal of Molecular Sciences·Renald Delanoue, Nuria M Romero
May 26, 2020·Cellular and Molecular Life Sciences : CMLS·Takashi KoyamaKim Rewitz
Dec 24, 2018·BMC Developmental Biology·Manishi SrivastavaVasu Sheeba
Jun 10, 2020·Neotropical Entomology·C Villagra, D Frías-Lasserre
Oct 8, 2020·Genetics·Michael J TexadaKim Rewitz
Mar 30, 2020·Current Biology : CB·Josefa CruzXavier Franch-Marro
Mar 2, 2021·Frontiers in Endocrinology·Celia G BarredoFrancisco A Martin
Sep 21, 2020·Current Opinion in Insect Science·Xueyang PanMichael B O'Connor
Nov 21, 2020·Current Opinion in Insect Science·Alina Malita, Kim Rewitz
May 7, 2021·Genetics·Michael J TexadaKim Rewitz
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Jan TaubenheimSebastian Fraune
Sep 26, 2021·Nature Communications·Nathalie ArquierPierre Léopold

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