PMID: 9428105Jan 15, 1998Paper

Prothrombin and factor X activator activities in the venoms of Viperidae snakes

Toxicon : Official Journal of the International Society on Toxinology
D YamadaT Morita

Abstract

A Ca(2+)-dependent prothrombin activator, carinactivase-1 (CA-1), was previously found in the venom of Echis carinatus leucogaster. In the present study, the activities of CA-1-like enzymes were screened in the venoms of various Viperidae snakes. The addition of 1 mM Ca2+ ions to the venoms of only Echis snakes in Viperidae produced considerably high prothrombin activator activity, indicating that only the Echis snake venoms contain not only the Ca(2+)-independent prothrombin activator, ecarin, but also Ca(2+)-dependent activator(s). CA-1-like activators and ecarin in the venom of each Echis snake were efficiently separated by Blue Sepharose column chromatography. The venoms of the various Viperidae snakes were also examined for factor X activator activity. The venoms of genera Daboia, Vipera, Cerastes, Echis, Calloselasma and Bothrops contained factor X activator activity in the presence of Ca2+ ions. Cerastes cerastes and Calloselasma rhodostoma venoms also had Ca(2+)-independent factor X activator activity.

References

Dec 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·J Rosing, G Tans
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·M F FurtadoL C Antonio
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·L Y YukelsonJ Rosing
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·M F el-AsmarA Tu
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Aug 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·T FaridM F el-Asmar

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Citations

Dec 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·Steven D Aird
Dec 16, 1998·Thrombosis Research·J W Govers-RiemslagG Tans
Mar 20, 1999·Biochimica Et Biophysica Acta·B R JenningsE G Shephard
Jul 15, 2015·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·V TurkovićR Dörfelt
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·R M Kini
Oct 22, 2016·Thrombosis Journal·Ren-Chieh WuLi-Kuang Chen
Jan 30, 2019·PLoS Neglected Tropical Diseases·Harry F WilliamsSakthivel Vaiyapuri
Jan 26, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sébastien LarréchéChristophe Martinaud
Jun 27, 2020·Journal of Veterinary Emergency and Critical Care·Ran NivyYaron Bruchim
Sep 8, 2010·Toxicon : Official Journal of the International Society on Toxinology·Thatiane C AntunesMarcelo L Santoro

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