Sep 1, 1977

Prothrombin complex concentrate

Archives of Internal Medicine
R T DeWitt, D I Feinstein


A hemophilliac with a factor VIII inhibitor was bleeding massively from an extensive surgical wound. After ten days of unsuccessful management by conservative measures, he was given a single infusion of prothrombin complex concentrate (Konyne). Bleeding stopped immediately and the wound healed without further recurrence of bleeding. Although the activated partial thromboplastin time shortened following the infusion, the exact physiologic mechanism whereby these concentrates bypass the need for factor VIII clotting activity is unknown.

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Mentioned in this Paper

Clotting Factor II Assay
F2 gene
Recurrent Malignant Neoplasm
Factor VIII antibody
Blood Coagulation Disorders
F8 gene
Prothrombin complex concentrates
Factor VIII Measurement

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