PMID: 9636195Jun 24, 1998Paper

Prothrombin deficiency results in embryonic and neonatal lethality in mice

Proceedings of the National Academy of Sciences of the United States of America
W Y SunS J Degen

Abstract

The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet activation, converts fibrinogen to fibrin, and activates regulatory pathways that both promote and ultimately suppress coagulation. However, several observations suggest that FII may serve a broader physiological role than simply stemming blood loss, including the identification of multiple G protein-coupled, thrombin-activated receptors, and the well-documented mitogenic activity of FIIa in in vitro test systems. To explore in greater detail the physiological roles of FII in vivo, FII-deficient (FII-/-) mice were generated. Inactivation of the FII gene leads to partial embryonic lethality with more than one-half of the FII-/- embryos dying between embryonic days 9.5 and 11.5. Bleeding into the yolk sac cavity and varying degrees of tissue necrosis were observed in many FII-/- embryos within this gestational time frame. However, at least one-quarter of the FII-/- mice survived to term, but ultimately they, too, developed fatal hemorrhagic events and died within a few days of birth. This study directly demonstrates that FII is important in maintaining vascular integrity during devel...Continue Reading

References

Feb 1, 1991·American Journal of Clinical Pathology·C E GreerM M Manos
Oct 29, 1991·Biochemistry·E W DavieW Kisiel
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L H ReidB H Koller
Feb 23, 1995·The American Journal of Cardiology·D BaykalM S Runge
Jan 1, 1994·Annals of the Rheumatic Diseases·R MorrisC J Morris
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·T H BuggeJ L Degen
Sep 5, 1996·Nature·P CarmelietD Collen
Jan 1, 1996·World Journal of Urology·M J Bussemakers, J A Schalken
Jan 1, 1996·Seminars in Thrombosis and Hemostasis·B W FestoffB A Citron
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·J R ToomeyG J Broze
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·J XueJ E Sadler
Sep 1, 1997·Environmental Science & Technology·K S Betts

❮ Previous
Next ❯

Citations

Aug 21, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sven DanckwardtAndreas E Kulozik
Oct 1, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Lisa D CupitWadie F Bahou
Feb 6, 2004·Blood Cells, Molecules & Diseases·Kenneth DayPudur Jagadeeswaran
Oct 27, 2004·The Veterinary Journal·Patricia A Gentry
May 23, 2000·Lancet·B Dahlbäck
Mar 29, 2003·Brain Research. Brain Research Reviews·Joanna M KarasinskaBrian F O'Dowd
Jun 26, 2003·Trends in Pharmacological Sciences·John H McVey
Jan 11, 2001·Trends in Cardiovascular Medicine·L L Leung, S W Hall
Jan 11, 2001·Journal of Pharmacological and Toxicological Methods·R J LeadleyA Gagnon
May 3, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Heyu Ni, John Freedman
May 24, 2003·Best Practice & Research. Clinical Haematology·Rashmi Sood, Hartmut Weiler
May 16, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·F PeyvandiP M Mannucci
Feb 15, 2002·Reviews in Clinical and Experimental Hematology·F PeyvandiP M Mannucci
Sep 29, 2005·Acta Paediatrica·Vineta Fellman
Jun 23, 2000·Journal of Pediatric Hematology/oncology·J S Palumbo, J L Degen
Feb 17, 2009·The Journal of Craniofacial Surgery·Martha M WerlerMatthew L Speltz
Mar 6, 2004·Journal of Thrombosis and Haemostasis : JTH·S S AcharyaUNKNOWN North American Rare Bleeding Disorder Study Group
Oct 28, 1998·The Journal of Clinical Investigation·L R JalbertF J Castellino
Jun 7, 2000·The Journal of Clinical Investigation·G C Parry, N Mackman
Mar 1, 2007·Blood·Aihua ZhuDavid Ginsburg
Feb 20, 2013·Journal of Molecular Endocrinology·S SivagurunathanE J Mackie
Mar 4, 2005·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Mari MitsuiTatsuo Yamamoto
Jun 1, 2014·PloS One·Susanna H M SlukaFelix C Tanner
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J ErlichN Mackman
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·S R Coughlin
Jun 3, 1999·British Journal of Haematology·W Y SunS J Degen
Jan 28, 2004·The Journal of Cell Biology·Lijun XiaRodger P McEver
Sep 23, 2014·Thrombosis Research·Valeria BafunnoPaolo Gresele
Sep 13, 2003·Chest·Enrico Di Cera
Mar 30, 2011·Hematology/oncology Clinics of North America·Gillian N Pike, Paula H B Bolton-Maggs
May 16, 2009·Blood Cells, Molecules & Diseases·Kenneth R Day, Pudur Jagadeeswaran
Mar 11, 2008·Molecular Aspects of Medicine·Enrico Di Cera
Nov 21, 2007·Thrombosis Research·Joseph S Palumbo, Jay L Degen
Jan 30, 2007·Hematology/oncology Clinics of North America·R Clive Landis
Oct 1, 2004·Journal of Thrombosis and Haemostasis : JTH·K G MannS Butenas
Sep 11, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·P H B Bolton-MaggsA D Mumford

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.