Prothrombin-related antigens in human aortic intima

Seminars in Thrombosis and Hemostasis
E B SmithS Carey

Abstract

Most plasma proteins are present in both normal and atherosclerotic intima, and their concentrations in intimal interstitial fluid are directly related to plasma concentration and molecular size. All intimal samples also contain soluble fibrin-fibrinogen-related antigens, consisting of variable mixtures of fibrinogen and fibrinogen and fibrin degradation products; the extracted washed tissue contains insoluble fibrin. It appears that the fibrinogen is subjected both to degradation and to conversion to fibrin, which in turn undergoes lysis. Biochemically, insoluble "fibrin" can be detected by incubating the washed tissue with plasmin, and assaying the fibrin degradation products that are released; they are released from all samples, including small amounts from normal intima. The fibrin could arise by incorporation of a mural fibrin clot and/or clotting of the fibrinogen within the intima, which contains a "cocktail" of clotting-related factors including prothrombin/thrombin-related antigens, antithrombin III (AT III), and other protease inhibitors: in recent experiments stripped intima was immediately treated with ethylenediaminetetraacetic acid, minced, extracted with Tris-buffered saline, and the extracts analyzed by sodium d...Continue Reading

Citations

Aug 2, 1996·Atherosclerosis·E B Smith
Mar 16, 2004·British Journal of Haematology·Anton J G Horrevoets
Jan 14, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A MigdalskiA Knapik-Bieniek
Jun 8, 2001·Circulation Research·C PattersonM S Runge
Dec 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Vivian de WaardHans Pannekoek
Jul 12, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Silvana MansillaMarie-Christine Bouton
Feb 8, 2018·Current Vascular Pharmacology·Andrej Fabjan, Fajko F Bajrović
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Marie-Christine BoutonMartine Jandrot-Perrus

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