Prothrombin time and activated partial thromboplastin time can be performed on the first tube

American Journal of Clinical Pathology
E L Gottfried, M M Adachi

Abstract

The current practice standard for coagulation studies on venous blood specifies the use of the second (or subsequent) tube for testing. Unless other tests are ordered, the first tube is discarded. This practice, derived from early experience using nondisposable materials, gained support from a report based on modern phlebotomy methods but inexperienced phlebotomists. For our study, paired blood specimens were collected by experienced phlebotomists from 175 outpatients whose physicians had ordered coagulation tests. Prothrombin time (PT) and activated partial thromboplastin time (APTT) were performed on the first and second tubes. Similar values were obtained for PT and APTT. (PT: n = 174; mean = 15.36 seconds; mean difference = 0.10 seconds; y = 1.02x - 0.28; t = 0.24; P>.81; r = 0.995; APTT: n = 160; mean = 38.25 seconds; mean difference = 0.48 seconds; y = 1.03x - 0.71; t = 0.25; P=.80; r = 0.993.) For coagulation tests on specimens collected by experienced phlebotomists, the first tube yields accurate results and need not be discarded.

Citations

Mar 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sébastien Lacroix-DesmazesVincent O Mallet
May 16, 2012·American Journal of Clinical Pathology·Yoko FukugawaTakashi Watanabe
Feb 26, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Kristi J SmockChristopher M Lehman
Apr 10, 2014·International Journal of Laboratory Hematology·C IndevuystP Meeus
Jan 23, 2010·American Journal of Clinical Pathology·Maarten T M RaijmakersFedde van der Graaf
Mar 28, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Nilgün TekkeşinOsman Eviyaoğlu
Oct 2, 2012·Journal of Thrombosis and Haemostasis : JTH·R LoeffenH M H Spronk
Jul 16, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A McCrawM Echenagucia
Dec 2, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Markas Masih, Naveen Kakkar
Aug 10, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giuseppe LippiEmmanuel J Favaloro

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