Prothrombin time in liver failure: time, ratio, activity percentage, or international normalized ratio?

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
A Robert, O Chazouillères

Abstract

Prothrombin time (PT) is a universal indicator of liver disease severity. However, variability in thromboplastin reagents leads to large interlaboratory differences in PT results. The aim of this study was to determine whether the use of the international normalized ratio (INR) or other modes of expression might achieve PT standardization in patients with liver failure. PT was measured with seven thromboplastin reagents with different sensitivities in plasmas from 27 patients with miscellaneous chronic and acute liver failure and, as a control population, 29 patients on oral anticoagulation therapy. PT was expressed in seconds, ratio, activity percentage, and INR. In patients with liver failure, only activity percentage expression eliminated variability in PT results obtained with the seven thromboplastins while INR, seconds, and ratio values remained significantly different (P < .01). In patients on oral anticoagulant therapy, only INR normalized PT results. We conclude that, in patients with liver failure, INR fails to yield a PT expression independent of the thromboplastin used and only activity percentage expression may provide a common international scale of PT reporting.

Citations

May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W R KimE R Dickson
Mar 17, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A O ShakilJ Rakela
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sylvie NaveauThierry Poynard
Oct 21, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O Chazouillères, A Robert
Dec 25, 2002·Journal of Pediatric Gastroenterology and Nutrition·Sylvie LebelKatryn N Furuya
Sep 1, 1999·Current Opinion in Hematology·T G DeLoughery
Oct 4, 2002·European Journal of Gastroenterology & Hepatology·Vincent CroquetPaul Calès
Feb 27, 2009·European Journal of Gastroenterology & Hepatology·Monika SchmidMarkus Peck-Radosavljevic
Feb 2, 2012·Seminars in Nuclear Medicine·Roelof J BenninkThomas M van Gulik
Jun 1, 2007·Current Opinion in Organ Transplantation·James F Trotter
Aug 8, 2008·Current Opinion in Organ Transplantation·Kiran M Bambha, Scott W Biggins
Feb 7, 2009·Journal of Clinical Gastroenterology·Jérôme BoursierChristophe Pilette
Feb 14, 2003·Mayo Clinic Proceedings·Russell H WiesnerRuud A F Krom
Sep 25, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James F TrotterCharles Phillips
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen H CaldwellB Gail Macik
Jul 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Armando TripodiPier Mannuccio Mannucci
May 22, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J F TrotterJ Kenison
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laurent BellestAnnie Robert
Jun 27, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Evangelos CholongitasAndrew K Burroughs
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·T LismanS H Caldwell
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·A Tripodi
Apr 26, 2006·Journal of Thrombosis and Haemostasis : JTH·J C Reverter
Jun 22, 2012·Journal of Clinical Apheresis·Shanna M Morgan, Nicole D Zantek
Jun 28, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Kryssia I Rodriguez-CastroMarco Senzolo
Dec 10, 2009·British Journal of Haematology·Lara N RobertsRoopen Arya
Apr 9, 2010·Journal of Thrombosis and Haemostasis : JTH·A TripodiUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the International Society on T
Mar 26, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuhiro TakikawaKazuyuki Suzuki
Mar 30, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R J PorteUNKNOWN Coagulation in Liver Disease Study Group
Jul 24, 2015·Biomarker Research·Erik Rahimi, Jen-Jung Pan
Apr 1, 2016·Anaesthesia·M A E Ramsay, J F Trotter
Nov 25, 2004·Clinics in Liver Disease·W R Kim, E R Dickson
Jul 5, 2005·Critical Care Clinics·Jody L Kujovich
Aug 8, 2009·British Journal of Haematology·Armando TripodiPier M Mannucci
Feb 27, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xavier XiolRoser Deulofeu
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·A TripodiA J Sanyal
Oct 30, 2016·Journal of Clinical Laboratory Analysis·Dennis KumralCurtis K Argo
Jul 10, 2013·Clinical and Molecular Hepatology·Hyung Joon Kim, Hyun Woong Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved