Prothrombotic factors do not increase the risk of recurrent ischemic events after cryptogenic stroke at young age: the FUTURE study

Journal of Thrombosis and Thrombolysis
Mijntje M I SchellekensFrank-Erik de Leeuw

Abstract

The role of hypercoagulable states and preceding infections in the etiology of young stroke and their role in developing recurrent ischemic events remains unclear. Our aim is to determine the prevalence of these conditions in patients with cryptogenic stroke at young age and to assess the long-term risk of recurrent ischemic events in patients with and without a hypercoagulable state or a recent pre-stroke infection with Borrelia or Syphilis. We prospectively included patients with a first-ever transient ischemic attack or ischemic stroke, aged 18-50, admitted to our hospital between 1995 and 2010. A retrospective analysis was conducted of prothrombotic factors and preceding infections. Outcome was recurrent ischemic events. Prevalence of prothrombotic factors did not significantly differ between patients with a cryptogenic stroke and with an identified cause (24/120 (20.0%) and 32/174 (18.4%) respectively). In patients with a cryptogenic stroke the long-term risk [mean follow-up of 8.9 years (SD 4.6)] of any recurrent ischemic event or recurrent cerebral ischemia did not significantly differ between patients with and without a hypercoagulable state or a recent infection. In patients with a cryptogenic stroke 15-years cumulativ...Continue Reading

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Citations

Jan 8, 2020·Brain Sciences·Beata Sarecka-Hujar, Ilona Kopyta
Sep 29, 2020·Stroke; a Journal of Cerebral Circulation·Yerim Kim, Soo Young Kim
Oct 24, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·S AfanasievG Altarescu

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Methods Mentioned

BETA
enzyme-linked assay
ELISA
coronary artery bypass

Software Mentioned

TOAST

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