Prothrombotic markers in asymptomatic dyslipidemic subjects.

Journal of Thrombosis and Thrombolysis
David KarasekDalibor Novotny

Abstract

The aim of this study was to evaluate the plasma levels of prothrombotic markers--von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA)--in asymptomatic subjects with dyslipidemia. Asymptomatic subjects with dyslipidemia and their relatives (n = 234) were assessed for lipids and prothrombotic markers. Individuals were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (n = 58, apoB < 1.2 g/l and TG < 1.5 mmol/l), DLP2 (n = 47, apoB < 1.2 g/l and TG ≥ 1.5 mmol/l), DLP3 (n = 31, apoB ≥ 1.2 g/l and TG < 1.5 mmol/l) and DLP4 (n = 98, apoB ≥ 1.2 g/l and TG ≥ 1.5 mmol/l). Associations between prothrombotic markers and risk factors for atherosclerosis, markers of insulin resistance, and the intima-media thickness of the common carotid artery (IMT) were assessed too. Significant differences in PAI-1 between normolipidemic phenotype--DLP1 (62.5 (35.9-82.9) ng/ml) and hypertriglyceridemic phenotypes--DLP2 (82.2 (61.1-122.1) ng/ml, p < 0.01) and DLP4 (91.4 (63.5-111.8) ng/ml, p < 0.001) after adjustment for age, sex and body mass index, were found. Levels of t-PA were different only between DLP1 and DLP4 (1.9 (0.9-3.3) ng/m...Continue Reading

References

Jan 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·L MussoniE Tremoli
Mar 1, 1992·Progress in Cardiovascular Diseases·H C Kwaan
Feb 11, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H CamposE J Schaefer
Mar 1, 1992·The Journal of Clinical Endocrinology and Metabolism·A VirkamäkiH Yki-Järvinen
Sep 1, 1989·Metabolism: Clinical and Experimental·P VagueC Atlan
Dec 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M L BotsD E Grobbee
May 1, 1994·Journal of Internal Medicine·G GeroulakosA G Shaper
Feb 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·C Bonithon-KoppP Ducimetière
May 1, 1996·American Journal of Hypertension·J R JengS M Shieh
Jan 1, 1996·International Journal of Clinical & Laboratory Research·H R Lijnen
Sep 30, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H ContoisE J Schaefer
May 13, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B Janand-DelenneP Vague
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·C KarlssonL M Carlsson
Dec 1, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·A Nordenhem, B Wiman
May 26, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P SchlingG Löffler
Jun 27, 2000·Diabetes/metabolism Research and Reviews·J P BastardB Hainque
Jul 6, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·V van HarmelenP Arner
Jul 17, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·E W KraegenA L Thompson
Oct 19, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·I MertensL Van Gaal
Feb 28, 2002·Thrombosis Research·Anita SchumacherHarald Arnesen
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Philippa J TalmudSteve E Humphries

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Citations

Oct 18, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·David KarasekDalibor Novotny
May 13, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dalibor NovotnyLudek Slavik
Mar 19, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Izabela R SantosKarina B Gomes
Jun 8, 2021·Metabolic Syndrome and Related Disorders·David KarasekLudek Slavik

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