Prothrombotic responses to exercise are little influenced by clopidogrel treatment

Thrombosis Research
C PernebyP Hjemdahl

Abstract

Adenosine diphosphate (ADP) is involved in shear-induced platelet activation, which may be important for platelet responses to stress. We therefore tested the hypothesis that ADP receptor antagonism by clopidogrel treatment would attenuate exercise-induced platelet activation. Fifteen healthy volunteers performed exhaustive exercise without and with clopidogrel pretreatment (75 mg/day; 7 days) in a randomised crossover study. Filtragometry readings (reflecting platelet aggregability in vivo) and 11-dehydro-thromboxane B(2) (TxM) in plasma were determined before and after exercise. Platelet and leukocyte activity, platelet-platelet (PPA), and platelet-leukocyte aggregates (PLAs) in vivo and their responsiveness to agonist stimulation in vitro were assessed by flow cytometry. Clopidogrel treatment inhibited ADP-induced platelet P-selectin expression by 72% (54-85%). Exercise increased platelet aggregation (filtragometry and PPAs), elevated plasma TxM, increased single platelet P-selectin expression, elevated circulating PLAs, and enhanced ADP and thrombin-stimulated P-selectin expression. Clopidogrel prolonged filtragometry readings and attenuated agonist stimulated P-selectin expression at rest, but did not influence TxM in plas...Continue Reading

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Citations

May 13, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Predrag PavlovićEmina Stamenković
Sep 18, 2009·Journal of Thrombosis and Thrombolysis·Olivier OrmezzanoJacques Machecourt
May 14, 2009·Platelets·Esben Hjorth MadsenSøren Risom Kristensen
Jun 9, 2016·The Journal of Nutrition, Health & Aging·T NickelM Halle
Jan 6, 2007·The Journal of Physiology·Gennady G YegutkinJosé González-Alonso
Dec 17, 2009·Thrombosis Research·Lazarela VucinicMatthew D Linden
Nov 2, 2014·American Journal of Hypertension·Eugenia GkaliagkousiStella Douma
Nov 12, 2015·BioMed Research International·Stefan Heber, Ivo Volf
Apr 7, 2011·Journal of the Royal Army Medical Corps·K WheatleyA Mellor
Aug 1, 2019·Expert Review of Cardiovascular Therapy·Sergey KachurRichard V Milani
Sep 30, 2009·Journal of Cardiovascular Medicine·Giancarla ScaloneFilippo Crea

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