PMID: 9189758Mar 1, 1997Paper

Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Y ShirayoshiN Nakatsuji

Abstract

Notch and its homologues are key regulatory receptors of the cell fate decision in various developmental processes. The int-3 oncogene was originally identified as a frequent target in Mouse Mammary Tumour Virus (MMTV)-induced mammary tumours and has been regarded as a Notch homologue, based on its similarity to the intracellular domain of Notch. Studies with int-3 transgenic mice have suggested that the int-3 transgene affects the differentiation capacity of stem cells and leads to neoplastic proliferation in epithelial cells. However, the exact nature and the in vivo expression pattern of the int-3 proto-oncogene are unknown. The function of gene products in embryogenesis is also not clear. We isolated cDNA clones corresponding to the proto-oncogene of int-3 and analysed its overall structure. The predicted amino acid sequence of the int-3 proto-oncogene contains the conserved motif found in Notch family receptors. Therefore, we name Notch-4 for the int-3 proto-oncogene. However, Notch-4 has fewer EGF repeats and shows less similarity to Notch, compared with other mammalian Notch homologues. In embryogenesis, the expression of Notch-4 was detected in endothelial cells of blood vessels forming tissues such as the dorsal aorta,...Continue Reading

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