Protocadherin-17 promoter methylation in serum-derived DNA is associated with poor prognosis of bladder cancer

The Journal of International Medical Research
Zhen-Guo LuoJian-Guo Ma

Abstract

To investigate the prognostic value of protocadherin 17 (PCDH17) promoter methylation in serum-derived DNA of patients with bladder cancer. DNA was isolated from serum of patients with bladder cancer and from age- and sex-matched controls. Methylation-specific polymerase chain reaction was used to examine the methylation status of the PCDH17 promoter. The correlations between methylation status and clinicopathological characteristics and overall survival were examined. PCDH17 promoter methylation was detected in 79/151 (52.3%) of patients with bladder cancer, and none of the 43 control subjects. Methylation was significantly associated with larger tumour diameter (>3 cm), high grade (G3) and advanced stage (T2-T4). Patients with PCDH17 promoter methylation had significantly shorter overall survival than those with unmethylated PCDH17 promoter. Methylation was an independent predictor of overall survival. PCDH17 promoter methylation was significantly associated with malignant behaviour and poor prognosis of bladder cancer. The detection of PCDH17 promoter methylation in serum-derived DNA may be a convenient and noninvasive predictive biomarker in routine clinical practice.

References

Jun 21, 2002·European Urology·Willem OosterlinckUNKNOWN European Association of Urology (EAU) Working Group on Oncological Urology
Aug 15, 2003·Current Opinion in Urology·Patrice Jichlinski
Jul 22, 2008·The Journal of Urology·Eun-Jung KimWun-Jae Kim
Feb 17, 2009·World Journal of Urology·Martine PloegLambertus A Kiemeney
Jun 23, 2010·CA: a Cancer Journal for Clinicians·Bruce L JacobsJames E Montie
Oct 6, 2010·Advances in Genetics·Marta Kulis, Manel Esteller
Aug 19, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Vera L CostaCarmen Jerónimo
Jun 16, 2012·Mutation Research·Lien Van De VoordeMarijn Speeckaert
Jul 25, 2012·Current Opinion in Urology·Maria FrantziAntonia Vlahou
Jul 26, 2012·Advances in Urology·Han HanGangning Liang
Sep 5, 2012·Nature Reviews. Genetics·Holger Heyn, Manel Esteller
Sep 8, 2012·Advances in Experimental Medicine and Biology·Carmen Marsit, Brock Christensen
Sep 19, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Susan R SturgeonKathleen F Arcaro
Jan 17, 2013·The Journal of International Medical Research·Y L LinJ G Ma
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 14, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Ioanna BalgkouranidouStylianos Kakolyris
Mar 30, 2013·Science·Mario L SuvàBradley E Bernstein
Jun 21, 2013·Expert Review of Molecular Diagnostics·Holger HeynManel Esteller
Jul 23, 2013·International Journal of Molecular Sciences·Yannick DelpuJérôme Torrisani

❮ Previous
Next ❯

Citations

Sep 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheng DangXianghui Wang
Sep 7, 2016·Disease Markers·Peng WuSong Wu
Jun 22, 2016·Investigative and Clinical Urology·Yong-June Kim, Wun-Jae Kim
Aug 31, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shiming YangDongyan Huang
Aug 6, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ying-Li LinJian-Guo Ma
Mar 8, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Ivana BaranovaMarcela Chmelarova
Feb 27, 2015·Expert Review of Molecular Diagnostics·Jörg EllingerDimo Dietrich
Jul 12, 2018·Cancer Biomarkers : Section a of Disease Markers·Ivana BaranovaMarcela Chmelarova
Dec 19, 2019·Frontiers in Genetics·Victor G MartinezJesus Maria Paramio
Jul 3, 2021·Cancers·Cora Palanca-BallesterAlfonso Calvo
Sep 21, 2021·Frontiers in Cell and Developmental Biology·Yufeng GuoDongkui Song

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.