Protocadherins at the Crossroad of Signaling Pathways

Frontiers in Molecular Neuroscience
Anna PanchoEve Seuntjens

Abstract

Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) in vertebrates. In this review, we summarize their discovery, expression mechanisms, and roles in neuronal development and cancer, thereby highlighting the context-dependent nature of their actions. We furthermore provide an extensive overview of current structural knowledge, and its implications concerning extracellular interactions between cPcdhs, ncPcdhs, and classical cadherins. Next, we survey the known molecular action mechanisms of Pcdhs, emphasizing the regulatory functions of proteolytic processing and domain shedding. In addition, we outline the importance of Pcdh intracellular domains in the regulation of downstream signaling cascades, and we describe putative Pcdh interactions with intracellular molecules including components of the WAVE complex, the Wnt pathway, and apoptotic cascades. Our overview combines molecular interaction data from different contexts, such as neural development and cancer. This comprehensive approach reveals potential common Pcdh signaling hubs, and points out future directions for research. Functional studies of such key fac...Continue Reading

References

May 15, 1997·Nature·D I StruttM Mlodzik
Jun 26, 1999·The Journal of Biological Chemistry·K YamagataP F Worley
May 16, 2000·Nature·J B WallingfordR M Harland
Sep 13, 2000·Nature·R Rosin-ArbesfeldM Bienz
Sep 26, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P BlancoN A Affara
Nov 22, 2001·Biochemical and Biophysical Research Communications·R HomayouniT Curran
Sep 17, 2002·Current Opinion in Cell Biology·Marcus Frank, Rolf Kemler
Dec 7, 2002·Neuron·Xiaozhong WangJoshua R Sanes
Mar 15, 2003·Developmental Cell·Mike A Heggem, Roger S Bradley
May 16, 2003·Journal of Neuroscience Research·Sacha KallenbachKeith Dudley
Feb 3, 2004·The Journal of Comparative Neurology·Karina MüllerChristoph Redies
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Feng Cong, Harold Varmus
Jul 24, 2004·The EMBO Journal·Araceli MedinaHerbert Steinbeisser
Jul 28, 2004·Molecular and Cellular Neurosciences·Martina BlankDarwin K Berg
Aug 7, 2004·The EMBO Journal·Frank UnterseherAlexandra Schambony
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Dec 22, 2004·The Journal of Biological Chemistry·Ingrid G HaasRolf Kemler
Feb 16, 2005·The Journal of Biological Chemistry·Boris HambschMartin K Schwarz
Apr 1, 2005·Neoplasia : an International Journal for Oncology Research·Anke WahaAndreas Waha

❮ Previous
Next ❯

Citations

Dec 3, 2020·Frontiers in Neuroscience·Zhilian Jia, Qiang Wu
May 7, 2021·Current Opinion in Neurobiology·Christabel X Tan, Cagla Eroglu
Jul 3, 2021·Journal of Clinical Medicine·Rossella BorghiClaudia Compagnucci
Aug 7, 2021·Acta Biomaterialia·Fiona R PassanhaVanessa L S LaPointe
Aug 8, 2021·Cells·Torsten ThalheimJoerg Galle

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
glycosylation
surface plasmon resonance
dissection
co-immunoprecipitation
nuclear translocation
GTPase
GTPases
ubiquitination

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Stacey L PeekJoshua A Weiner
Advances in Neurobiology
Takahiro Hirabayashi, Takeshi Yagi
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ming ShanGuoqiang Zhang
Cell Adhesion & Migration
Soo-Young KimHyun Kim
Seminars in Cell & Developmental Biology
Greg R PhillipsYan Mei Nie
© 2021 Meta ULC. All rights reserved