Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c-Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice

Phytotherapy Research : PTR
Sun-Hyang ParkJaemin Oh

Abstract

Protocatechuic acid (PCA) plays a critical role in nutritional metabolism; it is a major metabolite of anthocyanins, which are flavonoids with a range of health benefits. PCA has a variety of biological activities including anti-oxidant, antiinflammatory, anti-apoptosis, and anti-microbial activities. However, the pharmacological effect of PCA, especially on osteoclastogenesis, remains unknown. We examined the effect of PCA on receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation and bone resorption. PCA dose-dependently inhibited RANKL-induced osteoclast differentiation in mouse bone marrow macrophages (BMMs) and suppressed the bone-resorbing activity of mature osteoclasts. At the molecular level, PCA suppressed RANKL-induced phosphorylation of JNK among MAPKs only, without significantly affecting the early signaling pathway. PCA also suppressed RANKL-stimulated expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1) at the mRNA and protein levels, without altering c-Fos mRNA expression. Additionally, PCA down-regulated the expression of downstream osteoclastogenesis-related genes including β3-integrin, DC-STAMP, OC-STAMP, Atp6v0d2, CTR, and CtsK. Mice treated with PCA efficiently recove...Continue Reading

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Citations

Sep 25, 2019·Nutrients·Estefanía Márquez CamposMarie-Christine Simon
Aug 8, 2019·Environmental Science and Pollution Research International·Fiona Mary Antony, Kailas Wasewar
Aug 29, 2018·Oxidative Medicine and Cellular Longevity·Seon-A JangSe Chan Kang
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seon-A JangHyunil Ha
Nov 9, 2019·Current Stem Cell Research & Therapy·Chang LiuBaorong He
Mar 2, 2021·Drug and Chemical Toxicology·Solomon E OwumiAdegboyega K Oyelere
Aug 2, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiao SongDingkun Zhang

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