Protocatechuic acid protects brain mitochondrial function in streptozotocin-induced diabetic rats

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Yoswaris SemamingSiriporn C Chattipakorn

Abstract

Brain mitochondrial dysfunction has been demonstrated in diabetic animals with neurodegeneration. Protocatechuic acid (PCA), a major metabolite of anthocyanin, has been shown to exert glycemic control and oxidative stress reduction in the heart. However, its effects on oxidative stress and mitochondrial function in the brain under diabetic condition have never been investigated. We found that PCA exerted glycemic control, attenuates brain mitochondrial dysfunction, and contributes to the prevention of brain oxidative stress in diabetic rats.

References

Sep 6, 2008·Endocrinology·Judith A HerleinWilliam I Sivitz
Dec 2, 2008·Behavioural Brain Research·Edgardo O AlvarezFlavia Saravia
May 29, 2010·Journal of Basic and Clinical Physiology and Pharmacology·Ranganathan Harini, Kodukkur Viswanathan Pugalendi
Oct 30, 2010·Circulation Research·Ferdinando Giacco, Michael Brownlee
Apr 5, 2011·Journal of Agricultural and Food Chemistry·Chia-Yu LinMei-Chin Yin
Feb 23, 2013·Diabetes·Norman E Cameron
Oct 19, 2013·The Journal of Clinical Investigation·Laura L DuganKumar Sharma
Jul 31, 2014·The Journal of Endocrinology·Yoswaris SemamingNipon Chattipakorn
Mar 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Haider RazaFrank Christopher Howarth

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Citations

May 11, 2017·Nutrients·Dominik SzwajgierKatarzyna Pustelniak
Oct 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Eva TvrdáMiroslava Kačániová
Mar 29, 2021·Food Research International·S Mithul AravindS Chakkaravarthi
Nov 23, 2021·Molecular Nutrition & Food Research·Hiba N RajhaMarvin Edeas

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