Protocells programmed through artificial reaction networks.

Chemical Science
Yifan LyuWeihong Tan

Abstract

As the smallest unit of life, cells attract interest due to their structural complexity and functional reliability. Protocells assembled by inanimate components are created as an artificial entity to mimic the structure and some essential properties of a natural cell, and artificial reaction networks are used to program the functions of protocells. Although the bottom-up construction of a protocell that can be considered truly 'alive' is still an ambitious goal, these man-made constructs with a certain degree of 'liveness' can offer effective tools to understand fundamental processes of cellular life, and have paved the new way for bionic applications. In this review, we highlight both the milestones and recent progress of protocells programmed by artificial reaction networks, including genetic circuits, enzyme-assisted non-genetic circuits, prebiotic mimicking reaction networks, and DNA dynamic circuits. Challenges and opportunities have also been discussed.

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Citations

Nov 19, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xiaomin QianBrigitte Städler
May 6, 2021·Chemical Communications : Chem Comm·Lilin FengUlrich Schwaneberg
Nov 6, 2020·Chemical Communications : Chem Comm·Rosa Martí-CentellesBeatriu Escuder
Jul 17, 2021·Global Challenges·Pantelitsa DimitriouDavid Barrow
Jul 24, 2021·Biomaterials·David William GreenArtemis Stamboulis
Oct 1, 2021·Nature Communications·Yan ZhangMark P Styczynski
Oct 5, 2021·Chemical Society Reviews·Lanlan ChenHuanghao Yang
Oct 6, 2021·Journal of the American Chemical Society·Zhijie YangBartosz A Grzybowski

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Methods Mentioned

BETA
aminoacylation
PCR

Software Mentioned

Synells
AIRS
Biomolecular Implementation Of Protocellular Communication BIO...
PURE

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