Protochordate concordant xenotransplantation settings reveal outbreaks of donor cells and divergent life span traits

Developmental and Comparative Immunology
Noa Simon-BlecherB Rinkevich

Abstract

If fulminate rejection in allogeneic and xenogeneic engraftments is not an evolutionary relict feature, then any treatment that ablates the host surveillance's effector arms capabilities and eliminates graft vs. host reactivity should induce donor chimerism in transplant settings. We demonstrate here marked proliferative response of Botryllus (Urochordata) blood cells months following their infusions (2x10(4)-10(5) blood cells per host) into the concordant xenogeneic environment of irradiated Botrylloides soma. The state of infused cells was followed by Botryllus specific microsatellite alleles on DNA samples from host zooids and vascular system. Increased growth rates and life spans of engrafted hosts in some cases, and sudden chimerical death following the outbreak of donor cells in others, indicate a 'double-edged sword' expression of concurrent evolutionary selected mechanisms. This DES phenomenon in immunity underlies divergent stem cell competition phenomena in multicellular organisms, leading in mammals, to cases of autoimmune diseases vis-à-vis long-lasting microchimerism events following an iatrogenic transplantation.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B RinkevichI L Weissman
Jul 1, 1988·Science·G J SpangrudeI L Weissman
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L W Buss
Feb 11, 1982·Nature·V L ScofieldI L Weissman
Apr 15, 1994·Annals of the New York Academy of Sciences·S Ohno
May 13, 1999·Immunological Reviews·B G MagorI L Weissman
Jul 7, 1999·The Journal of Clinical Investigation·S MaloneyJ L Nelson
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·D S StonerI L Weissman
Mar 24, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D H Sachs
Jun 1, 2000·World Journal of Surgery·T E Starzl
Jan 3, 2001·Nature Medicine·C C Anderson, P Matzinger
Nov 5, 2002·Lupus·J L Nelson
Mar 1, 1998·Trends in Ecology & Evolution·T FagerströmP Sunnucks

❮ Previous
Next ❯

Citations

Jul 1, 2005·Marine Biotechnology·Ziva Lapidot, Baruch Rinkevich
May 2, 2008·BMC Evolutionary Biology·Keren-Or AmarBaruch Rinkevich
Jan 14, 2016·Scientific Reports·Baruch RinkevichRachel Ben-Shlomo
Jun 24, 2020·Journal of Molecular Evolution·Werner A Mueller, Baruch Rinkevich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2022 Meta ULC. All rights reserved