Protocol-based titration of intravenous terbutaline decreases length of stay in pediatric status asthmaticus

Pediatric Pulmonology
Christopher L Carroll, Craig M Schramm

Abstract

Although frequently used to treat status asthmaticus in children, intravenous (IV) terbutaline has not been shown to decrease hospital length of stay (LOS). We theorized that this lack of demonstrable benefit resulted from variations in dosing and titration, rather than the drug per se, and that intensive care unit (ICU) LOS would be shortened by the administration of terbutaline according to a protocol incorporating a quantitative assessment of severity of illness. We prospectively treated 20 consecutive children with status asthmaticus with IV terbutaline according to a protocol that titrated the dose based on a clinical asthma score, the Modified Pulmonary Index Score (MPIS). Data were compared to a historic cohort of the previous 20 consecutive ICU patients with status asthmaticus who were treated with IV terbutaline prior to initiation of the protocol. Patients who received terbutaline by standardized protocol had significantly shorter ICU LOS (3.5 +/- 1.1 vs. 5.0 +/- 2.0 days, P = 0.01), shorter hospital LOS (5.5 +/- 1.3 vs. 8.3 +/- 2.7 days, P < 0.01), and reduced hospital charges ($19,298 +/- $10,516 vs. $26,528 +/- $12,328, P = 0.04). The method of administration of IV terbutaline significantly influenced ICU length of...Continue Reading

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Citations

Nov 10, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Susan L BrattonUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Sep 8, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Knut Øymar, Thomas Halvorsen
Apr 13, 2013·Paediatric Respiratory Reviews·Muriel KoninckxMatthijs de Hoog
Mar 30, 2013·Critical Care Clinics·Christopher L Carroll, Kathleen A Sala
Sep 10, 2011·Pediatric Pulmonology·Christopher L CarrollCraig M Schramm
Jul 17, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Christopher L CarrollCraig M Schramm
Mar 7, 2014·World Journal of Pediatrics : WJP·Christopher L CarrollCraig M Schramm
May 27, 2008·Pediatric Pulmonology·Christopher L CarrollAaron R Zucker
May 3, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christopher L Carroll

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