Protocol for a Prospective (P) study to develop a model to stratify the risk (RI) of medication (M) related harm in hospitalized elderly (E) patients in the UK (The PRIME study)

BMC Geriatrics
Jennifer StevensonChakravarthi Rajkumar

Abstract

Medication related harm (MRH) is a common cause of morbidity and hospital admission in the elderly, and has significant cost implications for both primary and secondary healthcare resources. The development of risk prediction models has become an increasingly common phenomenon in medicine and can be useful to guide objective clinical decision making, resource allocation and intervention. There are no risk prediction models that are widely used in clinical practice to identify elderly patients at high risk of MRH following hospital discharge. The aim of this study is to develop a risk prediction model (RPM) to identify elderly patients at high risk of MRH upon discharge from hospital, and to compare this with routine clinical judgment. This is a multi-centre, prospective observational study following a cohort of patients for 8 weeks after hospital discharge. Data collection including patient characteristics, medication use, social factors and frailty will take place prior to patient discharge and then the patient will be followed up in the community over the next 8 weeks to determine if they have experienced MRH. Research pharmacists will determine whether patients have experienced MRH by prospectively reviewing records for unpl...Continue Reading

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Citations

May 24, 2018·British Journal of Clinical Pharmacology·Nikesh ParekhUNKNOWN PRIME study group
Jun 30, 2018·British Journal of Clinical Pharmacology·Nikesh ParekhUNKNOWN PRIME study group
May 19, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Greg ScuttChakravarthi Rajkumar
May 8, 2019·Hepatology Communications·Kelly L HaywardElizabeth E Powell
Sep 16, 2020·BMC Emergency Medicine·Maria Louise GamborgPeter Musaeus

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