Protocol for a systematic review of autologous fat grafting for wound healing

Systematic Reviews
Joshua LuckAfshin Mosahebi

Abstract

Autologous fat grafting is an emerging therapeutic option for cutaneous wounds. The regenerative potential of autologous fat relates to the presence of adipose-derived stem cells (ADSCs) within the stromal vascular fraction (SVF). ADSCs are capable of differentiating into fibroblasts and keratinocytes, as well as secreting soluble mediators with angiogenic and anti-inflammatory properties. However, to date, there has been no comprehensive assessment of the wound healing literature in humans. This systematic review aims to critically evaluate the efficacy and safety of autologous fat grafting in acute and chronic cutaneous wounds with an appraisal of the quality of evidence available. Following PRISMA guidelines, MEDLINE, Embase and Cochrane Library databases will be searched from inception to December 2017. All primary clinical studies in which wounds are treated with lipotransfer, cell-assisted lipotransfer (CAL), SVF products or isolated ADSCs will be eligible for inclusion. Study screening and data extraction will be conducted by two authors in duplicate. Our primary outcome measure will be the proportion of completely healed wounds at 12 weeks. Secondary outcome measures will include the proportion of partially healed wound...Continue Reading

References

Aug 29, 2006·Plastic and Reconstructive Surgery·Sydney R Coleman
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Dec 6, 2008·Facial Plastic Surgery Clinics of North America·William P Coleman
Aug 25, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J Bown, A J Sutton
Dec 29, 2015·Plastic and Reconstructive Surgery·Alexandra Condé-GreenMark S Granick
Jul 14, 2017·Annals of Medicine and Surgery·Nicolò BertozziEdoardo Raposio
Dec 1, 2017·Annals of Medicine and Surgery·Elisa BelliniEdoardo Raposio

❮ Previous
Next ❯

Citations

Nov 20, 2019·Clinics in Plastic Surgery·Nelson Sarto PiccoloMaria Thereza Sarto Piccolo

❮ Previous
Next ❯

Software Mentioned

Excel
ROBINS

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.