Protocol for the CONVERT trial-Concurrent ONce-daily VErsus twice-daily RadioTherapy: an international 2-arm randomised controlled trial of concurrent chemoradiotherapy comparing twice-daily and once-daily radiotherapy schedules in patients with limited stage small cell lung cancer (LS-SCLC) and good performance status

BMJ Open
Corinne Faivre-FinnFiona Blackhall

Abstract

Concurrent ONce-daily VErsus twice-daily RadioTherapy (CONVERT) is the only multicentre, international, randomised, phase III trial open in Europe and Canada looking at optimisation of chemoradiotherapy (RT) in limited stage small cell lung cancer (LS-SCLC). Following on from the Turrisi trial of once-daily versus twice-daily (BD) concurrent chemoradiotherapy, there is a real need for a new phase III trial using modern conformal RT techniques and investigating higher once-daily radiation dose. This trial has the potential to define a new standard chemo-RT regimen for patients with LS-SCLC and good performance status. 447 patients with histologically or cytologically proven diagnosis of SCLC were recruited from 74 centres in eight countries between 2008 and 2013. Patients were randomised to receive either concurrent twice-daily RT(45 Gy in 30 twice-daily fractions over 3 weeks) or concurrent once-daily RT(66 Gy in 33 once-daily fractions over 6.5 weeks) both starting on day 22 of cycle 1. Patients are followed up until death. The primary end point of the study is overall survival and secondary end points include local progression-free survival, metastasis-free survival, acute and late toxicity based on the Common Terminology Cri...Continue Reading

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Citations

Dec 22, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Matthew Quintin Fielding HattonJames Paul
Apr 1, 2017·The British Journal of Radiology·Nicki GroomCorinne Faivre-Finn
Jun 6, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ross A SooDavid R Spigel
Apr 28, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·N Rodriguez de DiosA Rodríguez
Sep 17, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rebecca Y TayRaffaele Califano
Nov 10, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Stephen G ChunJoe Y Chang

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Methods Mentioned

BETA
surgical resection
contraception
X-ray
biopsy

Clinical Trials Mentioned

ISRCTN91927162

Software Mentioned

CONVERT

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