Abstract
Concurrent ONce-daily VErsus twice-daily RadioTherapy (CONVERT) is the only multicentre, international, randomised, phase III trial open in Europe and Canada looking at optimisation of chemoradiotherapy (RT) in limited stage small cell lung cancer (LS-SCLC). Following on from the Turrisi trial of once-daily versus twice-daily (BD) concurrent chemoradiotherapy, there is a real need for a new phase III trial using modern conformal RT techniques and investigating higher once-daily radiation dose. This trial has the potential to define a new standard chemo-RT regimen for patients with LS-SCLC and good performance status. 447 patients with histologically or cytologically proven diagnosis of SCLC were recruited from 74 centres in eight countries between 2008 and 2013. Patients were randomised to receive either concurrent twice-daily RT(45 Gy in 30 twice-daily fractions over 3 weeks) or concurrent once-daily RT(66 Gy in 33 once-daily fractions over 6.5 weeks) both starting on day 22 of cycle 1. Patients are followed up until death. The primary end point of the study is overall survival and secondary end points include local progression-free survival, metastasis-free survival, acute and late toxicity based on the Common Terminology Cri...Continue Reading
References
Jun 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P Warde, D Payne
Dec 3, 1992·The New England Journal of Medicine·J P PignonB Lebeau
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N MurrayP Dixon
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B E JohnsonD C Ihde
Nov 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N C ChoiM Green
Jan 28, 1999·The New England Journal of Medicine·A T TurrisiD H Johnson
Nov 25, 2004·The Oncologist·Michael Huncharek, Ronald McGarry
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel B FriedMark A Socinski
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Ritsuko KomakiRoger W Byhardt
Dec 14, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D De RuysscherP Lambin
Mar 1, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hamid SheikhCorinne Faivre-Finn
Oct 22, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rovel ColacoCorinne Faivre-Finn
May 10, 2013·Chest·James R JettGregory P Kalemkerian
Mar 14, 2014·The British Journal of Radiology·N GroomC Faivre-Finn
Citations
Dec 22, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Matthew Quintin Fielding HattonJames Paul
Apr 1, 2017·The British Journal of Radiology·Nicki GroomCorinne Faivre-Finn
Jun 6, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ross A SooDavid R Spigel
Jun 24, 2017·The Lancet Oncology·Corinne Faivre-FinnUNKNOWN CONVERT Study Team
Nov 13, 2018·American Journal of Clinical Oncology·Shrinivas RathodArbind Dubey
Apr 26, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Y TayF Blackhall
Apr 28, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·N Rodriguez de DiosA Rodríguez
Aug 1, 2018·British Journal of Cancer·Mareike K ThompsonCharlotte E Coles
Dec 7, 2018·JAMA Oncology·Ahmed SalemCorinne Faivre-Finn
Oct 14, 2020·Health·Talia IsaacsFiona Stevenson
Sep 17, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rebecca Y TayRaffaele Califano
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Y TayF Blackhall
Nov 10, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Stephen G ChunJoe Y Chang