Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children's health in India and Sub-Saharan Africa.

BMC Nutrition
Giriraj R ChandakCaroline Hd Fall

Abstract

Animal studies have shown that nutritional exposures during pregnancy can modify epigenetic marks regulating fetal development and susceptibility to later disease, providing a plausible mechanism to explain the developmental origins of health and disease. Human observational studies have shown that maternal peri-conceptional diet predicts DNA methylation in offspring. However, a causal pathway from maternal diet, through changes in DNA methylation, to later health outcomes has yet to be established. The EMPHASIS study (Epigenetic Mechanisms linking Pre-conceptional nutrition and Health Assessed in India and Sub-Saharan Africa, ISRCTN14266771) will investigate epigenetically mediated links between peri-conceptional nutrition and health-related outcomes in children whose mothers participated in two randomized controlled trials of micronutrient supplementation before and during pregnancy. The original trials were the Mumbai Maternal Nutrition Project (MMNP, ISRCTN62811278) in which Indian women were offered a daily snack made from micronutrient-rich foods or low-micronutrient foods (controls), and the Peri-conceptional Multiple Micronutrient Supplementation Trial (PMMST, ISRCTN13687662) in rural Gambia, in which women were offered...Continue Reading

References

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Citations

Aug 28, 2020·Frontiers in Microbiology·Anja Saso, Beate Kampmann
Sep 6, 2020·The American Journal of Clinical Nutrition·Ayden SaffariUNKNOWN EMPHASIS Study Group
Feb 2, 2021·Annals of Nutrition & Metabolism·Melissa F Young, Usha Ramakrishnan

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Methods Mentioned

BETA
SGA
ELISA
pregnancy test
methylation profiling

Clinical Trials Mentioned

ISRCTN62811278
ISRCTN13687662

Software Mentioned

Atlantis
EMPHASIS

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